PNNL contributes to a nationwide research consortium investigating the molecular mechanisms triggered by endurance training.

Sequencing of microbiome and characterization of metabolome revealed significantly different functions of fine root systems from four temperate tree species in a 26-year-old common garden forest.

PNNL scientists developed a new method to map exactly how a fungus works with leafcutter ants in a complex microbial community to degrade plant material at the molecular level. The team’s insights are important for biofuels development.

Spatial proteomics enables researchers to link protein measurements to features in the image of a tissue sample, which are lost using standard approaches.

A streamlined informatics workflow that automatically processes complex data and provides the locations of double bonds in lipids.

The new PTM-Psi workflow opens the door for uncovering molecular insights within proteomics datasets.

Hi-C metagenomics-informed phage-host infection networks detected in soil pre- and post-drying.

PNNL scientists took thousands of measurements of firefighters in training to learn more about how the body responds to vigorous exercise.

Scientists screen for nanobodies that recognize wild type and mutant functional proteins to develop a framework to disrupt protein interactions that can cause disease.

PNNL scientists are creating new ways to learn more about the vast sea of chemicals that haven't been identified—yet.

Metabolomics analysis revealed differences in metabolome profiles for two distinct modes of fungal wood decay.

Data-driven autonomous technology to rapidly design and deliver antiviral interventions targeting SARS-CoV-2 to reduce drug discovery timeline and advance bio preparedness capabilities.

Advanced proteomic analysis tools dig deep into human blood plasma to understand the molecular nature of advanced alcoholic disease.

New research findings published in Science Advances (November 2022), help explain the progression of Alzheimer-related dementia in each patient. The findings outline a biological classification system that predicts disease severity.

PNNL scientists have developed a new mass spectrometry method for in-depth analysis of proteins in individual cells.

Data from increasingly complex mass spectrometry instruments met with adaptable data analysis solution.

Proteomics revealed molecular mechanisms by which the drug Verapamil could prolong beta cell function in early-onset type 1 diabetes patients.

Study highlights microbiome’s role in regulating xenobiotic metabolism.

Development of a one-meter path length miniature ion mobility spectrometer based on multilevel structures for lossless ion manipulations.

Researchers characterize protein signatures that indicate Acute Kidney Injury in COVID-19 patients.