PNNL

Abstract

A better understanding of treatment progression and recovery in pulmonary tuberculosis (TB) is crucial. This study analyzed longitudinal serum samples from pulmonary TB patients undergoing treatment to identify surrogate markers for TB-related outcomes. Previous proteome studies primarily focused on the 8-week timepoint in relation to culture conversion status. While this study confirms those observations, it also highlights some differences. The inclusion of additional end of treatment and post-treatment time points offers a more comprehensive assessment of treatment progression within the serum proteome. Examining the expression dynamics at these later times periods will help in the investigation of relapse patients and has provided indicative markers of response and recovery.