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Fundamental and Computational Sciences Directorate

Staff information

Natalie Sadler

IO Prototype & Pilot
Scientist
Pacific Northwest National Laboratory
PO Box 999
MSIN: J4-02
Richland, WA 99352

PNNL Publications

2016

  • Bennett K, NC Sadler, AT Wright, C Yeager, and MR Hyman. 2016. "Activity-based protein profiling of ammonia monooxygenase in Nitrosomonas europaea." Applied and Environmental Microbiology 82(8):2270-2279.  doi:10.1128/AEM.03556-15
  • Ortega C, LN Anderson, A Frando, NC Sadler, RW Brown, RD Smith, AT Wright, and C Grundner. 2016. "Systematic Survey of Serine Hydrolase Activity in Mycobacterium tuberculosis Defines Changes Associated with Persistence." Cell Chemical Biology 23(2):290-298.  doi:10.1016/j.chembiol.2016.01.003
  • Perez DM, ME Richards, R Parker, ME Berres, AT Wright, M Sifri, NC Sadler, N Tatiyaborworntham, and N Li. 2016. "Role of cytochrome P450 hydroxylase in the decreased accumulation of vitamin E in muscle from turkeys compared to that from chickens." Journal of Agricultural and Food Chemistry 64(3):671-680.  doi:10.1021/acs.jafc.5b05433
  • Sadler NC, HC Bernstein, MR Melnicki, MA Charania, EA Hill, LN Anderson, ME Monroe, RD Smith, AS Beliaev, and AT Wright. 2016. "Dinitrogenase Driven Photobiological Hydrogen Production Combats Oxidative Stress in Cyanothece sp. ATCC 51142." Applied Environmental Microbiology 82(24):7227-7235.  doi:10.1128/AEM.02098-16
  • Sadler NC, P Nandhikonda, BJM Webb-Robertson, C Ansong, LN Anderson, JN Smith, RA Corley, and AT Wright. 2016. "Hepatic cytochrome P450 activity, abundance, and expression throughout human development." Drug Metabolism and Disposition 44(7):984-91.  doi:10.1124/dmd.115.068593

2015

  • Sadler NC, and AT Wright. 2015. "Activity-Based Protein Profiling of Microbes." Current Opinion in Chemical Biology 24:139-144.  doi:10.1016/j.cbpa.2014.10.022
  • Bernstein HC, MA Charania, RS McClure, NC Sadler, MR Melnicki, EA Hill, LM Markillie, CD Nicora, AT Wright, MF Romine, and AS Beliaev. 2015. "Multi-omic Dynamics Associate Oxygenic Photosynthesis with Nitrogenase-mediated H2 production in Cyanothece sp. ATCC 51142." Scientific Reports 5:Article No. 16004.  doi:10.1038/srep16004
  • Liu Y, JK Fredrickson, NC Sadler, P Nandhikonda, RD Smith, and AT Wright. 2015. "Advancing Understanding of Microbial Bioenergy Conversion Processes by Activity-Based Protein Profiling." Biotechnology for Biofuels 8:Article No. 156.  doi:10.1186/s13068-015-0343-7
  • Wright AT, T Magnaldo, RL Sontag, LN Anderson, NC Sadler, PD Piehowski, Y Gache, and TJ Weber. 2015. "Deficient Expression of Aldehyde Dehydrogenase 1A1 Is Consistent with Increased Sensitivity of Gorlin Syndrome Patients to Radiation Carcinogenesis." Molecular Carcinogenesis 54(6):473-484.  doi:10.1002/mc.22115

2014

  • Wiedner SD, LN Anderson, NC Sadler, WB Chrisler, VK Kodali, RD Smith, and AT Wright. 2014. "Organelle-Specific Activity-Based Protein Profiling in Living Cells." Angewandte Chemie International Edition 53(11):2919-2922.  doi:10.1002/anie.201309135
  • Ansong C, NC Sadler, EA Hill, MP Lewis, EM Zink, RD Smith, AS Beliaev, A Konopka, and AT Wright. 2014. "Characterization of protein redox dynamics induced during light-to-dark transitions and nutrient limitation in cyanobacteria." Frontiers in Microbiology 5:Article No. 325.  doi:10.3389/fmicb.2014.00325
  • Sadler NC, MR Melnicki, MH Serres, ED Merkley, WB Chrisler, EA Hill, MF Romine, S Kim, EM Zink, S Datta, RD Smith, AS Beliaev, A Konopka, and AT Wright. 2014. "Live Cell Chemical Profiling of Temporal Redox Dynamics in a Photoautotrophic Cyanobacterium." ACS Chemical Biology 9(1):291-300.  doi:10.1021/cb400769v

2013

  • Crowell SR, A Sharma, S Amin, JJ Soelberg, NC Sadler, AT Wright, WM Baird, DE Williams, and RA Corley. 2013. "Impact of Pregnancy on the Pharmacokinetics of Dibenzo[def,p]chrysene in Mice." Toxicological Sciences 135(1):48-62.  doi:10.1093/toxsci/kft124

2012

  • Sadler NC, TE Angel, MP Lewis, LM Pederson, LM Chauvigne-Hines, SD Wiedner, EM Zink, RD Smith, and AT Wright. 2012. "Activity-Based Protein Profiling Reveals Mitochondrial Oxidative Enzyme Impairment and Restoration in Diet-Induced Obese Mice." PLoS One 7(10):Article No. e47996.  doi:10.1371/journal.pone.0047996

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