Staff information

PNNL Publications

2023

• Mejia Rodriguez D., H. Kim, N.C. Sadler, X. Li, P. Bohutskyi, M. Valiev, and W. Qian, et al. 2023. "PTM-Psi: A Python Package to Facilitate the Computational Investigation of Post-Translational Modification on Protein Structures and Their Impacts on Dynamics and Functions." Protein Science 32, no. 12:Art. No. e4822. PNNL-SA-186993. doi:10.1002/pro.4822

2022

• Killinger B.J., C. Whidbey, N.C. Sadler, A.J. DeLeon, N. Munoz Munoz, Y. Kim, and A.T. Wright. 2022. "Activity-based protein profiling identifies alternating activation of enzymes involved in the bifidobacterium shunt pathway or mucin degradation in the gut microbiome response to soluble dietary fiber." npj Biofilms and Microbiomes 8, no. 1:Art. No. 60. PNNL-SA-153236. doi:10.1038/s41522-022-00313-z
• Lin V.S., N.C. Sadler, P. Handakumbura, K.L. Tate, G.X. Lomas, and J. Ramirez. 2022. Characterizing proteases in sorghum drought response using activity-based protein profiling (ABPP). PNNL-33427. Richland, WA: Pacific Northwest National Laboratory. Characterizing proteases in sorghum drought response using activity-based protein profiling (ABPP)
• Smercina D.N., N.M. Zambare, K.S. Hofmockel, N.C. Sadler, E.L. Bredeweg, C.D. Nicora, and L. Markillie, et al. 2022. "Synthetic Soil Aggregates: Bioprinted Habitats for High Throughput Microbial Metaphenomics." Microorganisms 10, no. 5:Art. No. 944. PNNL-SA-171905. doi:10.3390/microorganisms10050944
• Wright A.T., S.J. Ramos-Hunter, and N.C. Sadler. 2022. Multiplexed Probing for Functional Capacity Measurements in Complex and Limited-Size Samples. PNNL-32901. Richland, WA: Pacific Northwest National Laboratory. Multiplexed Probing for Functional Capacity Measurements in Complex and Limited-Size Samples

2021

• Zegeye E., N.C. Sadler, G.X. Lomas, I.K. Attah, J.K. Jansson, K.S. Hofmockel, and C.R. Anderton, et al. 2021. "Activity-based protein profiling of chitin catabolism." Chembiochem 22, no. 4:717-723. PNNL-SA-156004. doi:10.1002/cbic.202000616

2020

• Lee J., N.C. Sadler, R.G. Egbert, C.R. Anderton, K.S. Hofmockel, J.K. Jansson, and H. Song. 2020. "Deep Learning Prediction of Interspecies Interactions from Self-organized Spatiotemporal Patterns of Co-evolving Organisms." In AIChE Annual Meeting, Conference Proceedings, November 16-20, 2020, Virtual, Online, 2020, Paper No. 168750. New York, New York:American Institute of Chemical Engineers. PNNL-SA-158208.
• Lee J., N.C. Sadler, R.G. Egbert, C.R. Anderton, K.S. Hofmockel, J.K. Jansson, and H. Song. 2020. "Deep Learning Predicts Microbial Interactions from Self-organized Spatiotemporal Patterns." Computational and Structural Biotechnology Journal 18. PNNL-SA-150281. doi:10.1016/j.csbj.2020.05.023
• Lin V.S., N.C. Sadler, and Y. Farris. 2020. Probing Cooperation and Competition between Paenibacillus polymyxa and Setaria viridis under Nutrient Stress. PNNL-30598. Richland, WA: Pacific Northwest National Laboratory. Probing Cooperation and Competition between Paenibacillus polymyxa and Setaria viridis under Nutrient Stress
• Naylor D.T., N.C. Sadler, A. Bhattacharjee, E.B. Graham, C.R. Anderton, R.S. McClure, and M.S. Lipton, et al. 2020. "Soil Microbiomes under Climate Change and Implications for Carbon Cycling." Annual Review of Environment and Resources 45. PNNL-SA-150059. doi:10.1146/annurev-environ-012320-082720

2019

• Lin V.S., N.C. Sadler, Y. Farris, E.H. Denis, L.C. Webber, and R.M. Francis. 2019. Identification of plant host and microbe model system for study of rhizophagy cycle. PNNL-29249. Richland, WA: Pacific Northwest National Laboratory. Identification of plant host and microbe model system for study of rhizophagy cycle
• Whidbey C., N.C. Sadler, R.N. Nair, R.F. Volk, A.J. DeLeon, L.M. Bramer, and S.J. Fansler, et al. 2019. "A Probe-Enabled Approach for the Selective Isolation and Characterization of Functionally Active Subpopulations in the Gut Microbiome." Journal of the American Chemical Society 141, no. 1:42-47. PNNL-SA-127532. doi:10.1021/jacs.8b09668

2018

• Sadler N.C., B.M. Webb-Robertson, T. Clauss, J.G. Pounds, R.A. Corley, and A.T. Wright. 2018. "High-fat diets alter the modulatory effects of xenobiotics on cytochrome P450 activities." Chemical Research in Toxicology 31, no. 5:308-318. PNNL-SA-126308. doi:10.1021/acs.chemrestox.8b00008
• Stoddard E.G., R.F. Volk, J.P. Carson, C.M. Ljungberg, T.A. Murphree, J.N. Smith, and N.C. Sadler, et al. 2018. "Multifunctional Activity-Based Protein Profiling of the Developing Lung." Journal of Proteome Research 17, no. 8:2623-2634. PNNL-SA-132239. doi:10.1021/acs.jproteome.8b00086

2017

• Bernstein H.C., R.S. McClure, V. Thiel, N.C. Sadler, Y. Kim, W.B. Chrisler, and E.A. Hill, et al. 2017. "Indirect interspecies regulation; transcriptional and physiological responses of a cyanobacterium to heterotrophic partnership." mSystems 2, no. 2:Article No. e00181-16. PNNL-SA-113682. doi:10.1128/mSystems.00181-16
• Stoddard E.G., B.J. Killinger, R.N. Nair, N.C. Sadler, R.F. Volk, S.O. Purvine, and A.K. Shukla, et al. 2017. "Activity-Based Probes for Isoenzyme- and Site-Specific Functional Characterization of Glutathione S- Transferases." Journal of the American Chemical Society 139, no. 45:16032-16035. PNNL-SA-127421. doi:10.1021/jacs.7b07378

2016

• Bennett K., N.C. Sadler, A.T. Wright, C. Yeager, and M.R. Hyman. 2016. "Activity-based protein profiling of ammonia monooxygenase in Nitrosomonas europaea." Applied and Environmental Microbiology 82, no. 8:2270-2279. PNNL-SA-114336. doi:10.1128/AEM.03556-15
• Ortega C., L.N. Anderson, A. Frando, N.C. Sadler, R.W. Brown, R.D. Smith, and A.T. Wright, et al. 2016. "Systematic Survey of Serine Hydrolase Activity in Mycobacterium tuberculosis Defines Changes Associated with Persistence." Cell Chemical Biology 23, no. 2:290-298. PNNL-SA-112430. doi:10.1016/j.chembiol.2016.01.003
• Perez D.M., M.E. Richards, R. Parker, M.E. Berres, A.T. Wright, M. Sifri, and N.C. Sadler, et al. 2016. "Role of cytochrome P450 hydroxylase in the decreased accumulation of vitamin E in muscle from turkeys compared to that from chickens." Journal of Agricultural and Food Chemistry 64, no. 3:671-680. PNNL-SA-108079. doi:10.1021/acs.jafc.5b05433
• Sadler N.C., H.C. Bernstein, M.R. Melnicki, M.A. Charania, E.A. Hill, L.N. Anderson, and M.E. Monroe, et al. 2016. "Dinitrogenase Driven Photobiological Hydrogen Production Combats Oxidative Stress in Cyanothece sp. ATCC 51142." Applied Environmental Microbiology 82, no. 24:7227-7235. PNNL-SA-113160. doi:10.1128/AEM.02098-16
• Sadler N.C., P. Nandhikonda, B.M. Webb-Robertson, C. Ansong, L.N. Anderson, J.N. Smith, and R.A. Corley, et al. 2016. "Hepatic cytochrome P450 activity, abundance, and expression throughout human development." Drug Metabolism and Disposition 44, no. 7:984-91. PNNL-SA-112422. doi:10.1124/dmd.115.068593

2015

• Bernstein H.C., M.A. Charania, R.S. McClure, N.C. Sadler, M.R. Melnicki, E.A. Hill, and L.M. Markillie, et al. 2015. "Multi-omic Dynamics Associate Oxygenic Photosynthesis with Nitrogenase-mediated H2 production in Cyanothece sp. ATCC 51142." Scientific Reports 5. PNNL-SA-111925. doi:10.1038/srep16004
• Liu Y., J.K. Fredrickson, N.C. Sadler, P. Nandhikonda, R.D. Smith, and A.T. Wright. 2015. "Advancing Understanding of Microbial Bioenergy Conversion Processes by Activity-Based Protein Profiling." Biotechnology for Biofuels 8. PNNL-SA-107650. doi:10.1186/s13068-015-0343-7
• Sadler N.C., and A.T. Wright. 2015. "Activity-Based Protein Profiling of Microbes." Current Opinion in Chemical Biology 24. PNNL-SA-105009. doi:10.1016/j.cbpa.2014.10.022
• Wright A.T., T. Magnaldo, R.L. Sontag, L.N. Anderson, N.C. Sadler, P.D. Piehowski, and Y. Gache, et al. 2015. "Deficient Expression of Aldehyde Dehydrogenase 1A1 Is Consistent with Increased Sensitivity of Gorlin Syndrome Patients to Radiation Carcinogenesis." Molecular Carcinogenesis 54, no. 6:473-484. PNNL-SA-95210. doi:10.1002/mc.22115

2014

• Ansong C., N.C. Sadler, E.A. Hill, M.P. Lewis, E.M. Zink, R.D. Smith, and A.S. Beliaev, et al. 2014. "Characterization of protein redox dynamics induced during light-to-dark transitions and nutrient limitation in cyanobacteria." Frontiers in Microbiology 5. PNNL-SA-101966. doi:10.3389/fmicb.2014.00325
• Sadler N.C., M.R. Melnicki, M.H. Serres, E.D. Merkley, W.B. Chrisler, E.A. Hill, and M.F. Romine, et al. 2014. "Live Cell Chemical Profiling of Temporal Redox Dynamics in a Photoautotrophic Cyanobacterium." ACS Chemical Biology 9, no. 1:291-300. PNNL-SA-93812. doi:10.1021/cb400769v
• Wiedner S.D., L.N. Anderson, N.C. Sadler, W.B. Chrisler, V.K. Kodali, R.D. Smith, and A.T. Wright. 2014. "Organelle-Specific Activity-Based Protein Profiling in Living Cells." Angewandte Chemie International Edition 53, no. 11:2919-2922. PNNL-SA-98713. doi:10.1002/anie.201309135

2013

• Crowell S.R., A. Sharma, S. Amin, J.J. Soelberg, N.C. Sadler, A.T. Wright, and W.M. Baird, et al. 2013. "Impact of Pregnancy on the Pharmacokinetics of Dibenzo[def,p]chrysene in Mice." Toxicological Sciences 135, no. 1:48-62. PNWD-SA-10207. doi:10.1093/toxsci/kft124

2012

• Sadler N.C., T.E. Angel, M.P. Lewis, L.M. Pederson, L.M. Chauvigne-Hines, S.D. Wiedner, and E.M. Zink, et al. 2012. "Activity-Based Protein Profiling Reveals Mitochondrial Oxidative Enzyme Impairment and Restoration in Diet-Induced Obese Mice." PLoS One 7, no. 10:Article No. e47996. PNNL-SA-88011. doi:10.1371/journal.pone.0047996