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Staff information

Torka Poet

Systems Toxicology
Scientist
Pacific Northwest National Laboratory
PO Box 999
MSIN: J4-02
Richland, WA 99352
509/371-6984

Research Interests

  • Life-stage specific sensitivities to environmental contaminants: exposure and outcome assessment for workers and their families.
  • Development of physiologically based pharmacokinetic and pharmacodynamic models for single agents and mixtures.
  • Development of multidisciplinary integrated research programs and teams to advance exposure assessment through the development and implementation of novel technologies and modeling.

Education and Credentials

  • Post-Doc, Cancer Group, Chemical Industry Institute of Toxicology, 1997
  • Ph.D., Pharmacology and Toxicology, University of Arizona, Tucson, AZ, 1995
  • M.S., Toxicology, University of Arizona, Tucson, AZ, 1991
  • B.A., Molecular, Cellular, & Developmental Biology, University of Colorado, Boulder, CO, 1988

PNNL Publications

2012

  • Timchalk C, JN Smith, AL Hjerpe, TS Poet, and SK Lee. 2012. "Regional Brain Dosimetry for the Organophosphorus Insecticide Chlorpyrifos in the Preweanling Rat." Chapter 13 in Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment. ACS Symposium Series, vol. 1099, ed. JB Knaak, C Timchalk and R Tornero-Velez, pp. 195-213.  American Chemical Society, Washington DC. 

2011

  • Hinderliter PM, PS Price, MJ Bartels, C Timchalk, and TS Poet. 2011. "Development of a Source-to-Outcome Model for Dietary Exposures to Insecticide Residues: An Example Using Chlorpyrifos." Regulatory Toxicology and Pharmacology 61(1):82-92.  doi:10.1016/j.yrtph.2011.06.004
  • Smith JN, C Timchalk, MJ Bartels, and TS Poet. 2011. "In Vitro Age-Dependent Enzymatic Metabolism of Chlorpyrifos and Chlorpyrifos-Oxon in Human Hepatic Microsomes and Chlorpyrifos-Oxon in Plasma." Drug Metabolism and Disposition 39(8):1353-1362.  doi:10.1124/dmd.111.038745
  • Lee SK, TS Poet, JN Smith, AL Hjerpe, R Gunawan, and C Timchalk. 2011. "IMPACT OF REPEATED NICOTINE AND ALCOHOL COEXPOSURE ON IN VITRO AND IN VIVO CHLORPYRIFOS DOSIMETRY AND CHOLINESTERASE INHIBITION." Journal of Toxicology and Environmental Health Part A 74(20):1334-50. 
  • Price PS, KD Schnelle, CB Cleveland, MJ Bartels, PM Hinderliter, C Timchalk, and TS Poet. 2011. "Application of a Source-to-Outcome Model for the Assessment of Health Impacts from Dietary Exposures to Insecticide Residues." Environmental Health Perspectives 61(1):23-31.  doi:10.1016/j.yrtph.2011.05.009

2010

  • Busby-Hjerpe AL, JA Campbell, JN Smith, S Lee, TS Poet, D Barr, and C Timchalk. 2010. "Comparative Pharmacokinetics of Chlorpyrifos versus its Major Metabolites Following Oral Administration in the Rat." Toxicology 268(1-2):55-63.  doi:10.1016/j.tox.2009.11.022
  • Lee S, TS Poet, JN Smith, AL Busby-Hjerpe, and C Timchalk. 2010. "Effect of In Vivo Nicotine Exposure on Chlorpyrifos Pharmacokinetics and Pharmacodynamics in Rats ." Chemico-Biological Interactions 184(3):449-457. 
  • Lee SK, TS Poet, JN Smith, AL Busby-Hjerpe, and C Timchalk. 2010. "Effect of in vivo nicotine exposure on chlorpyrifos pharmacokinetics and pharmacodynamics in rats." Chemico-Biological Interactions 184(3):449-457.  doi:10.1016/j.cbi.2010.01.024
  • Poet TS, BD Carlton, JA Deyo, and PM Hinderliter. 2010. "Hydroquinone PBPK Model Refinement and Application to Dermal Exposure." Food and Chemical Toxicology 48(11):3085-3092.  doi:10.1016/j.fct.2010.08.002
  • Poet TS, CR Kirman, M Bader, CV Thriel, ML Gargas, and PM Hinderliter. 2010. "Quantitative Risk Analysis for N-Methyl Pyrrolidone using Physiologically Based Pharmacokinetic and Benchmark Dose Modeling." Toxicological Sciences 113(2):468-482. 
  • Timchalk C, PM Hinderliter, and TS Poet. 2010. "Modeling Cholinesterase Inhibition." Chapter 6 in Quantitative Modeling in Toxicology, ed. K, Krishnan and M Andersen, pp. 137-165.  John Wiley & Sons, Ltd, New York. 

2009

  • Poet TS, H Wu, RA Corley, and KD Thrall. 2009. "In vitro glutathione conjugation of methyl iodide in rat, rabbit, and human blood and tissues." Inhalation Toxicology 21(5-7):524-530. 
  • Lee S, AL Busby, C Timchalk, and TS Poet. 2009. "Effects of Nicotine Exposure on In Vitro Metabolism of Chlorpyrifos in Male Sprague-Dawley Rats." Journal of Toxicology and Environmental Health Part A 72(2):74-82.  doi:10.1080/15287390802477288
  • Lowe ER, TS Poet, DL Rick, MS Marty, JL Mattson, C Timchalk, and MJ Bartels. 2009. "The Effect of Plasma Lipids on the Pharmacokinetics of Chlorpyrifos and the Impact on Interpretation of Blood Biomonioring Data." Toxicological Sciences 108(2):258-272. 
  • Lowe ER, TS Poet, DL Rick, MS Marty, JL Mattsson, C Timchalk, and MJ Bartels. 2009. "The effect of plasma lipids on the pharmacokinetics of chlorpyrifos and the impact on interpretation of blood biomonitoring data. ." Toxicological Sciences 108(2):258-272.  doi:10.1093/toxsci/kfp034
  • Smith JN, JA Campbell, AL Busby-Hjerpe, S Lee, TS Poet, D Barr, and C Timchalk. 2009. "Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration in the adult rat." Toxicology 261(1-2):47-58.  doi:10.1016/j.tox.2009.04.041

2008

  • Lipscomb JC, and TS Poet. 2008. "In Vitro Measurements of Metabolism for Application in Pharmacokinetic Modeling." Pharmacology & Therapeutics 118(1):82-103.  doi:10.1016/j.pharmthera.2008.01.006
  • Sweeney LM, KD Thrall, TS Poet, R Corley, TJ Weber, BJ Locey, J Clarkson, S Sager, and ML Gargas. 2008. "Physiologically based Pharmacokinetic Modeling of 1,4-Dioxane in Rats, Mice, and Humans." Toxicological Sciences 101(1):32-50.  doi:10.1093/toxsci/kfm251
  • Timchalk C, and TS Poet. 2008. "Development of a Physiologically Based Pharmacokinetic and Pharmacodynamic Model to Determine Dosimetry and Cholinesterase Inhibition for a Binary Mixture of Chlorpyrifos and Diazinon in the Rat." NeuroToxicology 29(3 Sp Iss):428-443.  doi:10.1016/j.neuro.2008.02.004

2007

  • Kousba AA, TS Poet, and C Timchalk. 2007. "AGE-RELATED BRAIN CHOLINESTERASE INHIBITION KINETICS FOLLOWING IN VITRO INCUBATION WITH CHLORPYRIFOS-OXON AND DIAZINON-OXON." Toxicological Sciences 95(1):147-155.  doi:doi:10.1093/toxsci/kfl123
  • Timchalk C, AA Kousba, and TS Poet. 2007. "An Age-Dependent Physiologically-Based Pharmacokinetic/Pharmacodynamic Model for the Organophosphorus Insecticide Chlorpyrifos in the Preweanling Rat." Toxicological Sciences 98(2):348-365.  doi:10.1093/toxsci/kfm119

2006

2005

  • Teeguarden JG, PJ Deisinger, TS Poet, JC English, WD Faber, HA Barton, RA Corley, and HJ Clewell, III. 2005. " Derivation of a human equivalent concentration for n-butanol using a physiologically based pharmacokinetic model for n-butyl acetate and metabolites n-butanol and n-butyric acid ." Toxicological Sciences 85(1):429-446. 
  • Corley RA, DM Grant, E Farris, KK Weitz, JJ Soelberg, KD Thrall, and TS Poet. 2005. "DETERMINATION OF AGE AND GENDER DIFFERENCES IN BIOCHEMICAL PROCESSES AFFECTING THE DISPOSITION OF 2-BUTOXYETHANOL AND ITS METABOLITES IN MICE AND RATS TO IMPROVE PBPK MODELING." Toxicology Letters 156(1):127-161. 
  • Timchalk C, TS Poet, MN Hinman, AL Busby, and AA Kousba. 2005. "PHARMACOKINETIC AND PHARMACODYNAMIC INTERACTION FOR A BINARY MIXTURE OF CHLORPYRIFOS AND DIAZINON IN THE RAT." Toxicology and Applied Pharmacology 205(1):31-42. 

2004

  • Poet TS, AA Kousba, SL Dennison, and C Timchalk. 2004. "Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Organophosphorus Pesticide Diazinon." NeuroToxicology 25(6):1013-1030.  doi:10.1016/j.neuro.2004.03.002
  • Poet TS, H Wu, JC English, and RA Corley. 2004. "Metabolic Rate Constants for Hydroquinone in F344 Rat and Human Liver Isolated Hepatocytes: Application to a PBPK model." Toxicological Sciences 82(1):9-25. 
  • Kousba AA, LG Sultatos, TS Poet, and C Timchalk. 2004. "Comparison of Chlorpyrifos-Oxon and Paraoxon Acetylcholinesterase Inhibition Dynamics: Potential role of a peripheral binding site ." Toxicological Sciences 80(2):239-248. 
  • Timchalk C, TS Poet, AA Kousba, JA Campbell, and Y Lin. 2004. "Noninvasive Biomonitoring Approaches to Determine Dosimetry and Risk Following Acute Chemical Exposure: Analysis of Lead or Organophosphate Insecticide in Saliva ." Journal of Toxicology and Environmental Health Part A 67:635-650. 

2003

  • Poet TS, H Wu, AA Kousba, and C Timchalk. 2003. "In Vitro Rat Hepatic and Intestinal Metabolism of the Organophosphate Pesticides Chlorpyrifos and Diazinon." Toxicological Sciences 72(2):193-200. 
  • Kousba AA, TS Poet, and C Timchalk. 2003. "Characterization of the In Vitro Kinetic Interaction of Chlorpyrifos-Oxon with Rat Salivary Cholinesterase: A Potential Biomonitoring Matrix." Toxicology 188(2-3):219-232. 
  • Poet TS, JJ Soelberg, KK Weitz, TJ Mast, RA Miller, BD Thrall, and RA Corley. 2003. "Mode of Action and Pharmacokinetic Studies of 2-Butoxyethanol in the Mouse with an Emphasis on Forestomach Dosimetry." Toxicological Sciences 71(2):176-189. 

2001

  • Timchalk C, TS Poet, Y Lin, KK Weitz, R Zhao, and KD Thrall. 2001. "Development of an Integrated Micro-Analytical System for Lead in Saliva and Linkage to a Physiologically Based Pharmacokinetic Model Describing Lead Saliva Secretion ." American Industrial Hygiene Association Journal 62(3):295-302. 

2000

  • Poet TS, KD Thrall, RA Corley, XY Hui, JA Edwards, KK Weitz, HI Maibach, and RC Wester. 2000. "Utility of real time breath analysis and physiologically based pharmacokinetic modeling to determine the percutaneous absorption of methyl chloroform in rats and humans ." Toxicological Sciences 54(1):42-51. 
  • Poet TS, RA Corley, KD Thrall, JA Edwards, H Tanojo, KK Weitz, X Hui, HI Maibach, and RC Wester. 2000. "Assessment of the Percutaneous Absorption of Trichloroethylene in Rats and Humans Using MS/MS Real Time Breath Analysis and Physiologically Based Pharmacokinetic Modeling." Toxicological Sciences 56(1):61-72. 
  • Poet TS. 2000. "Assessing Dermal Absorption." Toxicological Sciences 58(1):1-2. 
  • Thrall KD, TS Poet, RA Corley, H Tanojo, JA Edwards, KK Weitz, X Hui, HI Maibach, and RC Wester. 2000. "A Real-Time In-vivo Method for Studying the Percutaneous Absorption of Volatile Chemicals." International Journal of Occupational Environmental Health 6(2):96-103. 
  • Thrall KD, ME Vucelick, RA Gies, RC Zangar, KK Weitz, TS Poet, DL Springer, DM Grant, and JM Benson. 2000. "Comparative Metabolism of Carbon Tetrachloride in Rats, Mice and Hamsters Using Gas Uptake and PBPK Modeling." Journal of Toxicology and Environmental Health 60(8):531-548. 

1999

  • Thrall KD, TS Poet, and RA Corley. 1999. "An Innovative Method to Determine Percutaneous Absorption: Real-Time Analysis and Physiologically Based Pharmacokinetic Modeling ." Chapter 55 in Percutaneous Absorption: Drugs-Cosmetics-Mechanisms-Methodology, ed. Robert L. Bronaugh and Howard I. Maibach, pp. 929-937.  Marcel Dekker, Inc. , New York, NY. 

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