Staff information

Biography

Dr. Jian Zhi Hu is a research scientist at Pacific Northwest National Laboratory (PNNL), where he recently joined the advisory committee for the Transformational Materials Science Initiative. Dr. Hu joined PNNL in 2000. Prior to then, Dr. Hu was an assistant research professor at University of Utah’s Department of Chemistry from 2000 to 2001; a green chemistry program fellow at Los Alamos National Laboratory from 1998 to 2000; and a research professor and associate at several scientific institutions.

Dr. Hu has 24 years’ research experience in nuclear magnetic resonance (NMR) spectroscopy, magnetic resonance spectroscopy (MRS), and magnetic resonance imaging (MRI). Dr. Hu has developed many techniques, including:

• Slow and ultra-slow magic angle spinning (also known as magic angle turning, or MAT) techniques with a sample spinning rate of 1 to 100Hz for material characterization in solid-state NMR by accurately measuring the chemical-shift tensors of spin-1/2 nuclei in systems with complex molecular structures
• Techniques for in situ characterization of heterogeneous catalyst materials and reaction mechanisms
• High-resolution proton NMR metabolic profiling in vitro in human body fluids, ex vivo in excised intact tissues/organs, and in vivo in live animals
• High-resolution and -sensitivity proton metabolite NMR spectrum on samples with very limited masses and volumes.

Dr. Hu is an author and co-author of nearly 100 peer-reviewed publications. He holds four U.S. patents and has three pending patents. Additionally, he regularly attends scientific conferences and presents research-related material.

Research Interests

• Understanding the molecular mechanisms in hydrogen storage materials and lithium-ion batteries using NMR spectroscopy
• Ab initio calculations to predict molecular geometry and the principal values of chemical shift tensors (using quantum chemistry theory)
• NMR sensitivity enhancement using dynamic nuclear polarization, NMR data processing, NMR pulse sequence design, programming, testing, and NMR probe design and construction.

Education and Credentials

• Ph.D., Applied Physics, Wuhan Institute of Physics, Chinese Academy of Sciences
• M.S., Applied Physics, Wuhan Institute of Physics, Chinese Academy of Sciences
• B.S., Physics, Lanzhou University, China

Awards and Recognitions

• Special Academic President Award of the Chinese Academy of Sciences in 1995

PNNL Publications

2009

• Hu JZ, JA Sears, Jr, JH Kwak, DW Hoyt, Y Wang, and CHF Peden. 2009. "An Isotropic Chemical Shift-Chemical Shift Anisotropic Correlation Experiment Using Discrete Magic Angle Turning." Journal of Magnetic Resonance 198(1):105-110. 
• Hu JZ, JH Kwak, Y Wang, CHF Peden, H Zheng, D Ma, and X Bao. 2009. "Studies of the Active Sites for Methane Dehydroaromatization Using Ultrahigh-Field Solid-State Mo95 NMR Spectroscopy." Journal of Physical Chemistry C 113(7):2936-2942.  doi:10.1021/jp8107914
• Hu JZ, JH Kwak, Z Yang, X Wan, and LL Shaw. 2009. "Direct Observation of Ion Exchange in Mechanically Activated LiH+MgB2 System Using Ultra-High Field Nuclear Magnetic Resonance Spectroscopy." Applied Physics Letters 94(14):Art No.: 141905.  doi:10.1063/1.3110966
• Zhang Q, JZ Hu, DN Rommereim, MK Murphy, RP Phipps, DL Huso, and JF Dicello. 2009. "Application of High-Resolution H-1 MAS NMR Spectroscopy to the Analysis of Intact Bones from Mice Exposed to Gamma Radiation." Radiation Research 172(5):607-616.  doi:10.1667/RR1715.1
• Zhu K, JZ Hu, X She, J Liu, Z Nie, Y Wang, CHF Peden, and JH Kwak. 2009. "Characterization of Dispersed Heteropoly Acid on Mesoporous Zeolite Using Solid-State P-31 NMR Spin-Lattice Relaxation." Journal of the American Chemical Society 131(28):9715-9721.  doi:10.1021/ja901317r
• Baer DR, MH Engelhard, AR Felmy, JJ Ford, JZ Hu, AS Lea, P Nachimuthu, LV Saraf, JA Sears, and S Thevuthasan. 2009. "New Approaches for Characterizing Sensor and Other Modern Complex Materials." ECS Transactions 19(6):137-148.  doi:10.1149/1.3118546
• Kwak JH, JZ Hu, D Mei, CWW Yi, DH Kim, CHF Peden, L Allard, and J Szanyi. 2009. "Coordinatively unsaturated Al3+ centers as binding sites for active catalyst phases on ?-Al2O3." Science 325(5948):1670-1673.  doi:10.1126/science.1176745
• Murugesan V, SN Kerisit, CM Wang, Z Nie, KM Rosso, Z Yang, GL Graff, J Liu, and JZ Hu. 2009. "Effect of Chemical Lithium Intercalation into Rutile TiO2 Nanorods." Journal of Physical Chemistry C 113(32):14567-14574.  doi:10.1021/jp904148z
• Osborn W, T Markmaitree, LL Shaw, R Ren, JZ Hu, JH Kwak, and Z Yang. 2009. "Solid-State Hydrogen Storage: Storage Capacity,Thermodynamics and Kinetics." JOM. The Journal of the Minerals, Metals and Materials Society 61(4):45-51. 
• Webb-Robertson BJM, LA McCue, N Beagley, JE McDermott, DS Wunschel, SM Varnum, JZ Hu, NG Isern, GW Buchko, K Mcateer, JG Pounds, SJ Skerret, D Liggitt, and CW Frevert. 2009. "A Bayesian Integration Model of High-Throughput Proteomics and Metabolomics Data for Improved Early Detection of Microbial Infections." In Pacific Symposium on Biocomputing, vol. 14, pp. 451-463.  World Scientific Publishing Co., Singapore, Singapore. 

2008

• Hu JZ, JH Kwak, Z Yang, osborn, T Markmaitree, and LL Shaw. 2008. "Probing the Reaction Pathway of Dehydrogenation of the LiNH2 + LiH Mixture Using In Situ 1H NMR Spectroscopy ." Journal of Power Sources 181(1):116-119. 
• Hu JZ, JH Kwak, Z Yang, W Osborn, T Markmaitree, and LL Shaw. 2008. "Investigation of Mechanical Activation on Li-N-H Systems Using 6Li Magic Angle Spinning Nuclear Magnetic Resonance at Ultra-High Field ." Journal of Power Sources 182(1):278-283. 
• Herrera JE, JH Kwak, JZ Hu, Y Wang, and CHF Peden. 2008. "Effects of novel supports on the physical and catalytic properties of tungstophosphoric acid for alcohol dehydration reactions." Topics in Catalysis 49(3-4):259-267.  doi:10.1007/s11244-008-9081-4
• Hu JZ, DN Rommereim, KR Minard, A Woodstock, BJ Harrer, RA Wind, RP Phipps, and PJ Sime. 2008. "Metabolomics in Lung Inflammation: A High Resolution ¹H NMR Study of Mice Exposed to Silica Dust ." Toxicology Mechanisms and Methods 18(5):385-398.  doi:10.1080/15376510701611032
• Kwak JH, JZ Hu, AC Lukaski, DH Kim, J Szanyi, and CHF Peden. 2008. "The Role of PentaCoordinated Al3+ Ions in the High Temperature Phase Transformation of ?-Al2O3." Journal of Physical Chemistry C 112(25):9486-9492.  doi:10.1021/jp802631u
• Zheng H, D Ma, X Bao, JZ Hu, JH Kwak, Y Wang, and CHF Peden. 2008. "Direct Observation of the Active Center for Methane Dehydroaromatization Using an Ultrahigh Field 95Mo NMR Spectroscopy." Journal of the American Chemical Society 130(12):3722-3723.  doi:10.1021/ja7110916

2007

• Dixon DA, Z Dohnalek, MS Gutowski, JZ Hu, E Iglesia, BD Kay, J Liu, CHF Peden, L Wang, Y Wang, JM White, OA Bondarchuk, JE Herrera, J Kim, JH Kwak, T Stuchinskaya, HJ Zhai, CN Chisolm, and J Macht. 2007. "Early Transition Metal Oxides as Catalysts: Crossing Scales from Clusters to Single Crystals to Functioning Materials." In Frontiers in Catalysis Science. Meeting of the Catalysis and Chemical Transformations Program Chemical Sciences, Geosciences and Biosciences Division, Office of Basic Energy Sciences, U.S. Department of Energy Rockville, MD May 23-26, 2004, pp. 389-392.  Department of Energy, Washington, DC. 
• Kwak JH, JZ Hu, DH Kim, J Szanyi, and CHF Peden. 2007. "Penta-coordinated Al3+ ions as preferential nucleation sites for BaO on ?-Al2O3: an ultra-high magnetic field 27Al MAS NMR study." Journal of Catalysis 251(2):189-194.  doi:10.1016/j.jcat.2007.06.029
• Lu C, JZ Hu, JH Kwak, ZG Yang, R Ren, T Markmaitree, and LL Shaw. 2007. "Study the Effects of Mechanical Activation on Li-N-H Systems With 1H and 6Li Solid-State NMR." Journal of Power Sources 170(2):419-424.  doi:10.1016/j.jpowsour.2007.02.080

2006

• Herrera JE, JH Kwak, JZ Hu, Y Wang, and CHF Peden. 2006. "Synthesis of Nanodispersed Oxides of Vanadium, Titanium, Molybdenum, and Tungsten on Mesoporous Silica using Atomic Layer Deposition." Topics in Catalysis 39(3-4):245-255.  doi:10.1007/s11244-006-0063-0
• Herrera JE, JH Kwak, JZ Hu, Y Wang, CHF Peden, J Macht, and E Iglesia. 2006. "Synthesis, Characterization, and Catalytic Function of Novel Highly Dispersed Tungsten Oxide Catalysts on Mesoporous Silica ." Journal of Catalysis 239(1):200-211. 
• Hu JZ, DN Rommereim, RA Wind, KR Minard, and JA Sears. 2006. "A Simple Approach for Obtaining High Resolution, High Sensitivity ¹H NMR Metabolite Spectra of Biofluids with Limited Mass Supply." In Proceedings of the 2006 International Conference on Bioinformatics and Computational Biology (BIOCOMP '06), ed. HR Arabnia and H. Valafar, pp. 360-366.  CSREA Press, Las Vegas, NV. 
• Hu JZ, RA Wind, and DN Rommereim. 2006. "H-1 Relaxation Times of Metabolites in Biological Samples Obtained with Nondestructive Ex-vivo Slow-MAS NMR ." Magnetic Resonance in Chemistry 44(3):269-275.  doi:10.1002/mrc.1764
• Kwak JH, JE Herrera, JZ Hu, Y Wang, and CHF Peden. 2006. "A New Class of Highly Dispersed VOx Catalysts on Mesoporous Silica: Synthesis, Characterization, and Catalytic Activity in the Partial Oxidation of Ethanol." Applied Catalysis. A, General 300(2):109-119. 
• Wind RA, JZ Hu, and PD Majors. 2006. "Localized in Vivo Isotropic-Anisotropic Correlation 1H NMR Spectroscopy Using Ultraslow Magic Angle Spinning." Magnetic Resonance in Medicine 55(1):41-49. 
• Wind RA, and JZ Hu. 2006. "In vivo and ex vivo high-resolution ¹H NMR in biological systems using low-speed magic angle spinning." Progress in Nuclear Magnetic Resonance Spectroscopy 49(3-4):207-259. 

2005

• Dhamne A, W Xu, BG Fookes, Y Fan, L Zhang, SD Burton, JZ Hu, JJ Ford, and L An. 2005. "Polymer-Ceramic Conversion of Liquid Polyaluminasilazanes for SiAlCN Ceramics." Journal of the American Ceramic Society 88(9):2415-2419. 
• Hu JZ, JH Kwak, JE Herrera, Y Wang, and CHF Peden. 2005. "Line narrowing in H-1 MAS spectrum of mesoporous silica by removing adsorbed H2O using N-2 ." Solid State Nuclear Magnetic Resonance 27(3):200-205. 
• Wind RA, JZ Hu, and PD Majors. 2005. "Slow-MAS NMR: A New Technology for In Vivo Metabolomic Studies." Drug Discovery Today. Technologies 2(3):291-294.  doi:10.1016/j.ddtec.2005.08.009
• Wind RA, and JZ Hu. 2005. "Nuclear Magnetic Resonance Spectroscopy Applications: Proton NMR In Biological Objects Subjected To Magic Angle Spinning." Chapter 6 in Encyclopedia of Analytical Science, ed. Paul Worsfold, Alan Townshend, and Colin Poole, pp. 333-342.  Elsevier Academic Press, Amsterdam, Netherlands. 
• Wind RA, HC Bertram, and JZ Hu. 2005. "SLOW-MAS NMR METHODS TO STUDY METABOLIC PROCESSES IN VIVO AND IN VITRO." In Magnetic Resonance in Food Science: The Multivariate Challenge, ed. P. S. Belton, S. B. Engelsen, Hans Jørgen Jakobsen, pp. 156-165.  Royal Society of Chemistry, New York, NY. 

2004

• Hu JZ, RA Wind, JS Mclean, YA Gorby, CT Resch, and JK Fredrickson. 2004. "High Resolution 1H NMR Spectroscopy of Metabolically Active Microorganisms Using Non-Destructive Magic Angle Spinning." Spectroscopy 19(12):98-103. 
• Bertram HC, JZ Hu, DN Rommereim, RA Wind, and HJ Andersen. 2004. "Dynamic High-Resolution H-1 and P-31 NMR Spectroscopy and H-1 T-2 Measurements in Postmortem Rabbit Muscles Using Slow Magic Angle Spinning." Journal of Agricultural and Food Chemistry 52(9):2681-2688. 

2003

• Hu JZ, and RA Wind. 2003. "Sensitivity-enhanced Phase Corrected Ultra-slow Magic Angle Turning Using Multiple-Echo Data Acquisition ." Journal of Magnetic Resonance 163(1):149-162. 
• Wind RA, JZ Hu, and DN Rommereim. 2003. "High Resolution H-1 NMR Spectroscopy in a Live Mouse subjected to 1.5 Hz Magic Angle Spinning." Magnetic Resonance in Medicine 50(6):p. 1113-1119. 
• Wind RA, and JZ Hu. 2003. "Magnetic susceptibility effects in nuclear magnetic resonance spectroscopy of biological objects." In Recent Research Developments in Magnetism and Magnetic Materials, vol. 1, part 1, ed. S.G. Pandalai, pp. 147-169.  Transworld Research Network, Trivandrum, India. 

2002

• Hu JZ, and RA Wind. 2002. "The evaluation of different MAS techniques at low spinning rates in aqueous samples and in the presence of magnetic susceptibility gradients." Journal of Magnetic Resonance 159(1):92-100. 
• Hu JZ, DN Rommereim, and RA Wind. 2002. "High Resolution 1H NMR Spectroscopy in Rat Liver Using Magic Angle Turning at a 1 Hz Spinning Rate." Magnetic Resonance in Medicine 47(5):829-836. 
• Barich DH, JZ Hu, RJ Pugmire, and DM Grant. 2002. "Carbon-13 Chemical-Shift Tensors in Polycyclic Aromatic Compounds: Fluoranthene and Decacyclene." Journal of Physical Chemistry A 106:6477-6482. 

2001

• Wind RA, JZ Hu, and DN Rommereim. 2001. "High Resolution 1H NMR Spectroscopy in Organs and Tissues Using Slow Magic Angle Spinning." Magnetic Resonance in Medicine 46(2):213-218. 

2000

• Hu JZ, MS Solum, RA Wind, BL Nilsson, MA Peterson, RJ Pugmire, and DM Grant. 2000. "1H and 15N Dynamic Nuclear Polarization Studies of Carbazole." Journal of Physical Chemistry A 104:4413-4420. 
• Wind RA, B Shi, JZ Hu, MS Solum, PD Ellis, DM Grant, RJ Pugmire, CM Taylor, and CR Yonker. 2000. "H-1 Dynamic Nuclear Polarization in Supercritical Ethylene at 1.4 T." Journal of Magnetic Resonance 143(1):233-239.