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Fundamental and Computational Sciences Directorate

Staff information

Kevin Minard

Health Impacts & Exposure Science
Pacific Northwest National Laboratory
PO Box 999
MSIN: J4-18
Richland, WA 99352

PNNL Publications


  • Corley RA, S Kabilan, AP Kuprat, JP Carson, RE Jacob, KR Minard, JG Teeguarden, C Timchalk, S Pipavath, RW Glenny, and DR Einstein. 2015. "COMPARATIVE RISKS OF ALDEHYDE CONSTITUENTS IN CIGARETTE SMOKE USING TRANSIENT COMPUTATIONAL FLUID DYNAMICS/PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS OF THE RAT AND HUMAN RESPIRATORY TRACTS." Toxicological Sciences 146(1):65-88.  doi:10.1093/toxsci/kfv071


  • Teeguarden JG, VB Mikheev, KR Minard, WC Forsythe, W Wang, G Sharma, NJ Karin, SC Tilton, KM Waters, B Asgharian, O Price, JG Pounds, and BD Thrall. 2014. "Comparative Iron Oxide Nanoparticle Cellular Dosimetry and Response in Mice by the Inhalation and Liquid Cell Culture Exposure Routes." Particle and Fibre Toxicology 11:Article No. 46.  doi:10.1186/s12989-014-0046-4


  • Minard KR, MH Littke, W Wang, Y Xiong, JG Teeguarden, and BD Thrall. 2013. "Magnetic Particle Detection (MPD) for In-Vitro Dosimetry." Biosensors and Bioelectronics 43:88-93.  doi:10.1016/j.bios.2012.12.011
  • Sharma G, VK Kodali, MJ Gaffrey, W Wang, KR Minard, NJ Karin, JG Teeguarden, and BD Thrall. 2013. "Iron Oxide Nanoparticle Agglomeration Influences Dose-Rates and Modulates Oxidative Stress Mediated Dose-Response Profiles In Vitro." Nanotoxicology 8(6):663-675.  doi:10.3109/17435390.2013.822115


  • Corley RA, S Kabilan, AP Kuprat, JP Carson, KR Minard, RE Jacob, C Timchalk, RW Glenny, S Pipavath, TC Cox, C Wallis, R Larson, M Fanucchi, E Postlewait, and DR Einstein. 2012. "COMPARATIVE COMPUTATIONAL MODELING OF AIRFLOWS AND VAPOR DOSIMETY IN THE RESPIRATORY TRACTS OF RAT, MONKEY, AND HUMAN." Toxicological Sciences 128(2):500-516.  doi:10.1093/toxsci/kfs168
  • Minard KR, AP Kuprat, S Kabilan, RE Jacob, DR Einstein, JP Carson, and RA Corley. 2012. "Phase-Contrast MRI and CFD Modeling of Apparent 3He Gas Flow in Rat Pulmonary Airways." Journal of Magnetic Resonance 221:129-138.  doi:10.1016/j.jmr.2012.05.007
  • Neradilek MB, N Polissar, DR Einstein, RW Glenny, KR Minard, JP Carson, X Jiao, RE Jacob, TC Cox, E Postlewait, and RA Corley. 2012. "BRANCH-BASED MODEL FOR THE DIAMETERS OF THE PULMONARY AIRWAYS: ACCOUNTING FOR DEPARTURES FROM SELF-CONSISTENCY AND REGISTRATION ERRORS." The Anatomical Record 295(6):1027-1044.  doi:10.1002/ar.22476
  • Thrall BD, KR Minard, JG Teeguarden, and KM Waters. 2012. Multiscale Toxicology - Building the Next Generation Tools for ToxicologyPNNL-21916, Pacific Northwest National Laboratory, Richland, WA. 


  • Ferguson RM, KR Minard, AP Khandhar, and KM Krishnan. 2011. "Optimizing Magnetite Nanoparticles for Mass Sensitivity in Magnetic Particle Imaging ." Medical Physics 38(3):1619-1626.  doi:10.1118/1.3554646


  • Carson JP, DR Einstein, KR Minard, M Fanucchi, C Wallis, and RA Corley. 2010. "High resolution lung airway cast segmentation with proper topology suitable for computational fluid dynamic simulations." Computerized Medical Imaging and Graphics 34(7):572-857.  doi:10.1016/j.compmedimag.2010.03.001
  • Ferguson RM, AP Khandhar, KR Minard, and KM Krishnan. 2010. "SIZE-OPTIMIZED MAGNETITE NANOPARTICLES FOR MAGNETIC PARTICLE IMAGING." In Proceedings of the First International Workshop on Magnetic Particle Imaging: Magnetic Nanoparticles: Particle Science, Imaging Technology, and Clinical Applications, ed. TM Buzug, et al, pp. 53-59.  World Scientific Publishing, Hackensack, NJ. 
  • Hinderliter PM, KR Minard, G Orr, WB Chrisler, BD Thrall, JG Pounds, and JG Teeguarden. 2010. "ISDD: A Computational Model of Particle Sedimentation, Diffusion and Target Cell Dosimetry for In Vitro Toxicity Studies." Particle and Fibre Toxicology 7(November):Article No. 36.  doi:10.1186/1743-8977-7-36
  • Jacob RE, BG Amidan, JJ Soelberg, and KR Minard. 2010. "In Vivo MRI of Altered Proton Signal Intensity and T2 Relaxation in a Bleomycin Model of Pulmonary Inflammation and Fibrosis." Journal of Magnetic Resonance Imaging 31(5):1091-1099.  doi:10.1002/jmri.22166
  • Minard KR. 2010. "Magnetic Particle Imaging." In Encyclopedia of Spectroscopy and Spectrometry 2nd edition, pp. 1426-1434.  Elsevier, Amsterdam, Netherlands. 


  • Corley RA, KR Minard, S Kabilan, DR Einstein, AP Kuprat, JR harkema, J Kimbell, ML Gargas, and JH Kinzell. 2009. "Magnetic resonance imaging and computational fluid dynamics (CFD) simulations of rabbit nasal airflows for the development of hybrid CFD/PBPK models ." Inhalation Toxicology 21(5-7):512-518. 
  • Corley RA, KR Minard, S Kabilan, DR Einstein, AP Kuprat, JR Harkema, J Kimbell, ML Gargas, and JH Kinzell. 2009. "Magnetic Resonance Imaging and Computational Fluid Dynamics (CFD) Simulations of Rabbit Nasal Airflows for the Development of Hybrid CFD/PBPK Models." Inhalation Toxicology 21(6):512-518. 
  • Ferguson MR, KR Minard, and KM Krishnan. 2009. "Optimization of nanoparticle core size for magnetic particle imaging." Journal of Magnetism and Magnetic Materials 321(10):1548-1551. 


  • Einstein DR, B Neradilak, N Pollisar, KR Minard, C Wallis, M Fanucchi, JP Carson, AP Kuprat, S Kabilan, R Jacob, and R Corley. 2008. "An Automated Self-similarity Analysis of the Pulmonary Tree of the Sprague-Dawley Rat." The Anatomical Record 291(12):1628-1648.  doi:10.1002/ar.20771
  • Jacob RE, KR Minard, GJ Laicher, and C Timchalk. 2008. "3D He-3 diffusion MRI as a local in vivo morphometric tool to evaluate emphysematous rat lungs." Journal of Applied Physiology 105:1291-1300.  doi:10.1152/japplphysiol.90375.2008
  • Minard KR, RE Jacob, G Laicher, DR Einstein, AP Kuprat, and RA Corley. 2008. "MR Imaging of Apparent 3He Gas Transport in Narrow Pipes and Rodent Airways ." Journal of Magnetic Resonance 194(2):182-191.  doi:10.1016/j.jmr.2008.07.006


  • Jacob RE, G Laicher, and KR Minard. 2007. "3D MRI of Non-Gaussian 3He Gas Diffusion in the Rat Lung." Journal of Magnetic Resonance 188(2):357-366.  doi:10.1016/j.jmr.2007.08.014
  • Carey SA, KR Minard, LL Trease, JG Wagner, GM Garcia, CA Ballinger, J Kimbell, CG Plopper, RA Corley, E Postlewait, and JR Harkema. 2007. "Three-Dimensional Mapping of Ozone-Induced Injury in the Nasal Airways of Monkeys Using Magnetic Resonance Imaging and Morphometric Techniques." Toxicologic Pathology 35(1):27-40. 


  • Minard KR, DR Einstein, RE Jacob, S Kabilan, AP Kuprat, C Timchalk, LL Trease, and RA Corley. 2006. "Application of Magnetic Resonance (MR) Imaging for the Development and Validation of Computational Fluid Dynamic (CFD) Models of the Rat Respiratory System." Inhalation Toxicology 18(10):787-794.  doi: 10.1080/08958370600748729
  • Minard KR, VV Vishwanathan, PD Majors, LQ Wang, and PC Rieke. 2006. "Magnetic Resonance Imaging (MRI) of PEM Dehydration and Gas Manifold Flooding During Continuous Fuel Cell Operation." Journal of Power Sources 161(2):856-863. 


  • Alam TM, BR Cherry, KR Minard, and MC Celina. 2005. "Relaxation Nuclear Magnetic Resonance Imaging Investigation of Heterogeneous Aging in a Hydroxy-Terminated Polybutadiene-Based Elastomer ." Macromolecules 38(26):10694-10701. 
  • Majors PD, JS Mclean, GE Pinchuk, JK Fredrickson, YA Gorby, KR Minard, and RA Wind. 2005. "NMR methods for in-situ biofilm metabolism studies." Journal of Microbiological Methods 62(3):337-344. 
  • Minard KR, C Timchalk, and RA Corley. 2005. "T2-Shortening of 3He Gas by Magnetic Microspheres." Journal of Magnetic Resonance 173(1):90-96. 


  • Minard KR, GR Holtom, LE Kathmann, PD Majors, BD Thrall, and RA Wind. 2004. "Simultaneous 1H PFG-NMR and Confocal Microscopy of Monolayer Cell Cultures: Effects of Apoptosis and Necrosis on Water Diffusion and Compartmentalization." Magnetic Resonance in Medicine 52(3):495-505. 


  • Majors PD, KR Minard, EJ Ackerman, GR Holtom, DF Hopkins, CI Parkinson, TJ Weber, and RA Wind. 2002. "A combined confocal and magnetic resonance microscope for biological studies." Review of Scientific Instruments 73(12):4329-4338. 


  • Timchalk C, HE Trease, LL Trease, KR Minard, and RA Corley. 2001. "Potential Technology for Studying Dosimetry and Response to Airborne Chemical and Biological Pollutants." Toxicology and Industrial Health 17(5-10):270-6. 



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