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Staff information


Rick Jacob

Health Impacts & Exposure Science
Pacific Northwest National Laboratory
PO Box 999
MSIN: J4-18
Richland, WA 99352

Education and Credentials

  • Ph.D., physics, University of Utah
  • BS, physics, Arizona State University

Affiliations and Professional Service

  • American Physical Society
  • American Physiological Society
  • American Association for the Advancement of Science

PNNL Publications


  • Jacob RE, WJ Lamm, DR Einstein, M Krueger, RW Glenny, and RA Corley. 2015. "Comparison of CT-derived Ventilation Maps with Deposition Patterns of Inhaled Microspheres in Rats." Experimental Lung Research 41(3):135-145.  doi:10.3109/01902148.2014.984085


  • Jacob RE, and JP Carson. 2014. "Automated Measurement of Heterogeneity in CT Images of Healthy and Diseased Rat Lungs using Variogram Analysis of an Octree Decomposition." BMC Medical Imaging 14:Article No. 1.  doi:10.1186/1471-2342-14-1
  • Cooper WJ, RC Albertson, RE Jacob, and MW Westneat. 2014. "Re-description and Reassignment of the Damselfish Abudefduf luridus (Cuvier, 1830) Using Both Traditional and Geometric Morphometric Approaches." Copeia 2014(3):473-480.  doi:10.1643/CI-13-074
  • Miller FJ, B Asgharian, JD Schroeter, O Price, RA Corley, DR Einstein, RE Jacob, TC Cox, S Kabilan, and T Bentley. 2014. "Respiratory tract lung geometry and dosimetry model for male Sprague-Dawley rats." Inhalation Toxicology 26(9):524-544.  doi:10.3109/08958378.2014.925991


  • Jacob RE, JP Carson, M Thomas, and DR Einstein. 2013. "Dynamic Multiscale Boundary Conditions for 4D CT Images of Healthy and Emphysematous Rat." PLoS One 8(6):Article No. e65874.  doi:10.1371/journal.pone.0065874
  • Jacob RE, MK Murphy, JA Creim, and JP Carson. 2013. "Detecting Radiation-Induced Injury Using Rapid 3D Variogram Analysis of CT Images of Rat Lungs." Academic Radiology 20(10):1264-1271.  doi:10.1016/j.acra.2013.07.001
  • Jacob RE, SM Colby, S Kabilan, DR Einstein, and JP Carson. 2013. "In Situ Casting and Imaging of the Rat Airway Tree for Accurate 3D Reconstruction." Experimental Lung Research 39(6):249-257.  doi:10.3109/01902148.2013.801535
  • Einstein DR, AP Kuprat, X Jiao, JP Carson, DM Einstein, RA Corley, and RE Jacob. 2013. "An Efficient Algorithm for Mapping Imaging Data to 3D Unstructured Grids in Computational Biomechanics." International Journal for Numerical Methods in Biomedical Engineering 29(1):1-16.  doi:10.1002/cnm.2489


  • Asgharian B, O Price, G McClellan, RA Corley, DR Einstein, RE Jacob, JR Harkema, SA Carey, E Schelegle, D Hyde, J Kimbell, and FJ Miller. 2012. "Development of a Rhesus Monkey Lung Geometry Model and Application to Particle Deposition in Comparison to Humans." Inhalation Toxicology 24(13):869-899.  doi:10.3109/08958378.2012.725782
  • Corley RA, S Kabilan, AP Kuprat, JP Carson, KR Minard, RE Jacob, C Timchalk, RW Glenny, S Pipavath, TC Cox, C Wallis, R Larson, M Fanucchi, E Postlewait, and DR Einstein. 2012. "COMPARATIVE COMPUTATIONAL MODELING OF AIRFLOWS AND VAPOR DOSIMETY IN THE RESPIRATORY TRACTS OF RAT, MONKEY, AND HUMAN." Toxicological Sciences 128(2):500-516.  doi:10.1093/toxsci/kfs168
  • Freed AD, DR Einstein, JP Carson, and RE Jacob. 2012. Viscoelastic Model for Lung Parenchyma for Multi-Scale Modeling of Respiratory System, Phase II: Dodecahedral Micro-ModelPNNL-21287, Pacific Northwest National Laboratory, Richland, WA. 
  • Minard KR, AP Kuprat, S Kabilan, RE Jacob, DR Einstein, JP Carson, and RA Corley. 2012. "Phase-Contrast MRI and CFD Modeling of Apparent 3He Gas Flow in Rat Pulmonary Airways." Journal of Magnetic Resonance 221:129-138.  doi:10.1016/j.jmr.2012.05.007
  • Neradilek MB, N Polissar, DR Einstein, RW Glenny, KR Minard, JP Carson, X Jiao, RE Jacob, TC Cox, E Postlewait, and RA Corley. 2012. "BRANCH-BASED MODEL FOR THE DIAMETERS OF THE PULMONARY AIRWAYS: ACCOUNTING FOR DEPARTURES FROM SELF-CONSISTENCY AND REGISTRATION ERRORS." The Anatomical Record 295(6):1027-1044.  doi:10.1002/ar.22476


  • Jacob RE, and WJ Lamm. 2011. "Stable Small Animal Mechanical Ventilation for Dynamic Lung Imaging to Support Computational Fluid Dynamics Models." PLoS One 6(11):e27577.  doi:10.1371/journal.pone.0027577


  • Jacob RE, BG Amidan, JJ Soelberg, and KR Minard. 2010. "In Vivo MRI of Altered Proton Signal Intensity and T2 Relaxation in a Bleomycin Model of Pulmonary Inflammation and Fibrosis." Journal of Magnetic Resonance Imaging 31(5):1091-1099.  doi:10.1002/jmri.22166
  • Gierada DS, JC Woods, RE Jacob, AJ Bierhals, CK Choong, ST Bartel, YV Chang, NA Das, C Hong, B Lutey, JH Ritter, TK Pilgram, JD Cooper, GA Patterson, RJ Battafarano, BF Meyers, DA Yablonskiy, and MS Conradi. 2010. "Emphysema Quantification in Inflation-Fixed Lungs Using Low-Dose Computed Tomography and 3He Magnetic Resonance Imaging." Journal of Computer Assisted Tomography 34(5):773-779.  doi:10.1097/RCT.0b013e3181e480f9


  • Jacob RE, JP Carson, KM Gideon, BG Amidan, CL Smith, and KM Lee. 2009. "Comparison of Two Quantitative Methods of Discerning Airspace Enlargement in Smoke-Exposed Mice." PLoS One 4(8):E6670.  doi:10.1371/journal.pone.0006670
  • Gierada DS, JC Woods, AJ Bierhals, ST Bartel, JH Ritter, CK Choong, NA Das, C Hong, TK Pilgram, YV Chang, RE Jacob, JC Hogg, RJ Battafarano, JD Cooper, BF Meyers, GA Patterson, DA Yablonskiy, and MS Conradi. 2009. "Effects of Diffusion Time on Short-Range Hyperpolarized 3He Diffusivity Measurements in Emphysema." Journal of Magnetic Resonance Imaging 30(4):801-808.  doi:10.1002/jmri.21912


  • Jacob RE, KR Minard, GJ Laicher, and C Timchalk. 2008. "3D He-3 diffusion MRI as a local in vivo morphometric tool to evaluate emphysematous rat lungs." Journal of Applied Physiology 105:1291-1300.  doi:10.1152/japplphysiol.90375.2008
  • Einstein DR, B Neradilak, N Pollisar, KR Minard, C Wallis, M Fanucchi, JP Carson, AP Kuprat, S Kabilan, R Jacob, and R Corley. 2008. "An Automated Self-similarity Analysis of the Pulmonary Tree of the Sprague-Dawley Rat." The Anatomical Record 291(12):1628-1648.  doi:10.1002/ar.20771
  • Minard KR, RE Jacob, G Laicher, DR Einstein, AP Kuprat, and RA Corley. 2008. "MR Imaging of Apparent 3He Gas Transport in Narrow Pipes and Rodent Airways ." Journal of Magnetic Resonance 194(2):182-191.  doi:10.1016/j.jmr.2008.07.006


  • Jacob RE, G Laicher, and KR Minard. 2007. "3D MRI of Non-Gaussian 3He Gas Diffusion in the Rat Lung." Journal of Magnetic Resonance 188(2):357-366.  doi:10.1016/j.jmr.2007.08.014


  • Minard KR, DR Einstein, RE Jacob, S Kabilan, AP Kuprat, C Timchalk, LL Trease, and RA Corley. 2006. "Application of Magnetic Resonance (MR) Imaging for the Development and Validation of Computational Fluid Dynamic (CFD) Models of the Rat Respiratory System." Inhalation Toxicology 18(10):787-794.  doi: 10.1080/08958370600748729

Selected Publications


  • Jacob RE, KR Minard, G Laicher, C Timchalk. 2008. "3D 3He Diffusion MRI as a local in vivo morphometric tool to evaluate emphysematous rat lungs." Journal of Applied Physiology 105:1291-1300.
  • Minard KR, RE Jacob, G Laicher, DR Einstein, AP Kuprat, and RA Corley. 2008. "MR Imaging of Apparent 3He Gas Transport in Narrow Pipes and Rodent Airways." Journal of Magnetic Resonance 194:182-191.


  • Minard KR, DR Einstein, RE Jacob, S Kabilan, A Kuprat, C Timchalk, L Trease, and RA Corley. 2006. "Application of Magnetic Resonance (MR) Imaging for the Development and Validation of Computational Fluid Dynamic (CFD) Models of the Rat Respiratory System," Inhalation Toxicology 18:787-794.

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