Staff information

Research Interests

• single molecule spectroscopy
• atomic force microscopy
• ultrafast spectroscopy

Education and Credentials

• Ph.D., Chemistry, University of Minnesota
• M.S., Chemistry, Peking University
• B.S., Chemistry, Peking University

Affiliations and Professional Service

• American Chemical Society

PNNL Publications

2009

• Lei C, D Hu, and EJ Ackerman. 2009. "Clay Nanoparticle-Supported Single-Molecule Fluorescence Spectroelectrochemistry." Nano Letters 9(2):655-658. 
• Wang D, D Choi, J Li, Z Yang, Z Nie, R Kou, D Hu, CM Wang, LV Saraf, J Zhang, IA Aksay, and J Liu. 2009. "Self-assembled TiO2-Graphene Hybrid Nanostructures for Enhanced Li-ion Insertion ." ACS Nano 3(4):907-914. 

2008

• Hu D, Z Tian, W Wu, W Wan, and AD Li. 2008. "Photoswitchable Nanoparticles Enable High-Resolution Cell Imaging: PULSAR Microscopy." Journal of the American Chemical Society 130(46):15279-15281.  doi:10.1021/ja805948u
• Lei C, D Hu, and EJ Ackerman. 2008. "Single-molecule Fluorescence Spectroelectrochemistry of Cresyl Violet." Chemical Communications (43):5490-5492.  doi:10.1039/b812161c
• Li G, D Hu, GG Xia, JM White, and ZC Zhang. 2008. "High Throughput Operando Studies using Fourier Transform Infrared Imaging and Raman Spectroscopy." Review of Scientific Instruments 79:074101.  doi:10.1063/1.2949389

2007

• Orr G, DJ Panther, JL Phillips, BJ Tarasevich, A Dohnalkova, D Hu, JG Teeguarden, and JG Pounds. 2007. "Submicron and Nanoscale Inorganic Particles Exploit the Actin Machinery to be Propelled Along Microvillilike Structures into Alveolar Cells." ACS Nano 1(5):463-475.  doi:10.1021/nn700149r
• Pan D, D Hu, R Liu, X Zeng, S Kaplan, and HP Lu. 2007. "Fluctuating Two-State Light Harvesting in a Photosynthetic Membrane." Journal of Physical Chemistry C 111(25):8948-8956.  doi:10.1021/jp071493y

2006

• Hu D, and HP Lu. 2006. "Single Molecule Electron Transfer Process of Ruthenium Complexes." In Ultrasensitive and Single-Molecule Detection Technologies, 21-22 and 24 January 2006, San Jose, California, USA . Proceedings of the SPIE, vol. 6092, ed. Jörg Enderlein and Zygmunt K. Gryczynski, pp. 60927-1 -- 60927-7.  Society of Photo-optical Instrumentation Engineers, Bellingham, WA. 
• Liu R, D Hu, X Tan, and HP Lu. 2006. "Revealing Two-State Protein-Protein Interaction of Calmodulin by Single-Molecule Spectroscopy." Journal of the American Chemical Society 128(31):10034-10042. 
• Pan D, NA Klymyshyn, D Hu, and HP Lu. 2006. "Tip-Enhanced Near-Field Raman Spectroscopy Probing Single Dye-Sensitized TiO2 Nanoparticles." Applied Physics Letters 88(9):Art. No. 093121. 
• Zhang T, SN Danthi, J Xie, D Hu, HP Lu, and KH Li. 2006. "Live Cell Imaging of the Endocytosis and the Intracellular Trafficking of Multifunctional Lipid Nanoparticles." In Proceedings of the SPIE, vol. 6095, p. Art. No. 6095D.  S P I E, Bellingham, WA. 

2005

• Hu D, and HP Lu. 2005. "Single-Molecule Triplet-State Photon Antibunching at Room Temperature." Journal of Physical Chemistry B 109(20):9861-9864. 
• Orr G, D Hu, S Ozcelik, L Opresko, HS Wiley, and SD Colson. 2005. "Cholesterol Dictates the Freedom of EGF Receptors and HER2 in the Plane of the Membrane." Biophysical Journal 89(2):1362-1373.  doi:10.1529/biophysj.104.056192
• Link S, D Hu, WS Chang, GD Scholes, and PF Barbara. 2005. "Nernatic Solvation of Segmented Polymer Chains." Nano Letters 5(9):1757-1760.  doi:10.1021/nl051108l
• Pan D, D Hu, and HP Lu. 2005. "Probing Inhomogeneous Vibrational Reorganization Energy Barriers of Interfacial Electron Transfer." Journal of Physical Chemistry B 109(34):16390-16395. 

2004

• Hu D, and HP Lu. 2004. "Placing Single-Molecule T4 Lysozyme Enzymes on a Bacterial Cell Surface: Toward Probing Single-Molecule Enzymatic Reaction in Living Cells." Biophysical Journal 87:656-661. 
• Hu D, M Micic, NA Klymyshyn, YD Suh, and HP Lu. 2004. "Correlated Topographic and Spectroscopic Imaging by Combined Atomic Force Microscopy and Optical Microscopy." Journal of Luminescence 107(1-4):4-12. 
• Biju VP, M Micic, D Hu, and HP Lu. 2004. "Intermittent Single-Molecule Interfacial Electron Transfer Dynamics." Journal of the American Chemical Society 126(30):9374-9381. 
• Micic M, D Hu, YD Suh, GJ Newton, MF Romine, and HP Lu. 2004. "Correlated Atomic Force Microscopy and Flourescence Lifetime Imaging of Live Bacterial Cells." Colloids and Surfaces. B, Biointerfaces 34:205-212. 
• Tan X, D Hu, TC Squier, and HP Lu. 2004. "Probing Nanosecond Protein Motions of Calmodulin by Single-Molecule Fluorescence Anisotropy." Applied Physics Letters 85(12):2420-2422. 
• Tan X, D Hu, TC Squier, and HP Lu. 2004. "Probing Nanosecond Protein Motions of Calmodulin by Single-Molecule Fluorescence Anisotropy." Applied Physics Letters 85(12):2420-2422. 
• Tan X, P Nalbant, A Toutchkine, D Hu, ER Vorpagel, KM Hahn, and HP Lu. 2004. "Single-Molecule Study of Protein-Protein Interaction Dynamics in a Cell Signaling System." Journal of Physical Chemistry B 108(2):737-744. 

2003

• Hu D, and HP Lu. 2003. "Single-Molecule Nanosecond Anisotropy Dynamics of Tethered Protein Motions." Journal of Physical Chemistry B 107(2):618-626. 
• Hu D, M Micic, NA Klymyshyn, YD Suh, and HP Lu. 2003. "Correlated Topographic and Spectroscopic Imaging Beyond Diffraction Limit by Atomic Force Microscopy Metallic Tip-Enhanced Near-Field Flourescence Lifetime Microscopy." Review of Scientific Instruments 74(7):3347-3355. 
• Chen Y, D Hu, ER Vorpagel, and HP Lu. 2003. "Probing Single-Molecule T4 Lysozyme Conformational Dynamics by Intramolecular Fluorescence Energy Transfer." Journal of Physical Chemistry B 107:7947-7956.