February 27, 2022
Book Chapter

Lessons learned from studying Histoplasma capsulatum extracellular vesicles

Abstract

Histoplasma capsulatum is a major endemic mycosis. Our laboratories have demonstrated that H. capsulatum produces extracellular vesicles (EV) that are loaded with diverse compounds that influence virulence. We have further shown that H. capsulatum dynamically regulates the loading and release of fungal EV in response to stimuli and growth conditions. This chapter details the current knowledge of EV biology in H. capsulatum and the impact of this information on our understanding of this important process that is closely linked to pathogenesis.

Published: February 27, 2022

Citation

Zamith-Miranda D., L.R. Alves, E.S. Nakayasu, and J.D. Nosanchuk. 2021. Lessons learned from studying Histoplasma capsulatum extracellular vesicles. In Fungal Extracellular Vesicles: Biological Roles. Current Topics in Microbiology and Immunology, edited by M. Rodrigues and G. Janbon. 13-18. PNNL-SA-169908. doi:10.1007/978-3-030-83391-6_2

Research topics

Integrative Omics