PNNL

Dr. Paul Wilson is a senior biomedical scientist specializing in radiation biology. He is also the Biological Systems Sciences group leader in in Pacific Northwest National Laboratory’s Biological Sciences Division. Wilson earned a PhD in cellular and molecular radiobiology from Colorado State University in Fort Collins with Dr. Joel Bedford and completed a postdoctoral fellowship in DNA repair with Dr. Larry Thompson in the Biosciences and Biotechnology Division at Lawrence Livermore National Laboratory (LLNL). After converting to a senior staff scientist at LLNL, Wilson was recruited to Brookhaven National Laboratory. There, he managed a radiobiology team and radiobiology operations at the NASA Space Radiation Laboratory, a national charged particle accelerator user facility that is jointly managed by the Department of Energy and NASA. Wilson’s research focuses on studying the impact of ionizing radiation exposures across a broad range of doses, dose rates, and linear energy transfer values using in vitro cell culture and in vivo animal models; identifying and testing promising radiation medical countermeasures; and evaluating the impacts of inter-individual genetic variation on ionizing radiation-associated health risks in exposed individuals and populations, including astronauts on extended space missions.

• Cancer Biology
• Cancer Genomics
• Cancer Research
• Cancer Stem Cells
• Cancer Therapeutics
• Chemical, Biological, Radiological, Nuclear, or Explosive (CBRNE) Response
• DNA Damage
• DNA Repair
• Irradiation
• Irradiation and Dosimetry
• Radiation Biology
• Radiation Damage
• Radiation Dosimetry and Measurement
• Radiation Effects
• Radiation Modeling and Simulation
• Radiation Therapy

• PhD in Radiological Health Sciences, Colorado State University
• BS in Physics, University of Washington
• BA in Biological Anthropology, University of Washington

Radiation Research Society

2022

Jiang N, Xie B, Xiao W, Fan M, Xu S, Duan Y, Hamsafar Y, Evans AC, Huang J, Zhou W, Lin X, Ye N, Wanggou S, Chen W, Jing D, Fragoso RC, Dugger BN, Wilson PF, Coleman MA, Xia S, Li X, Sun LQ, Monjazeb AM, Wang A, Murphy WJ, Kung HJ, Lam KS, Chen HW, Li JJ. (2022). Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion. Nat. Commun. 13 (1): 1511. doi: 10.1038/s41467-022-29137-3. PMID: 35314680.

Bennett PV, Johnson AM, Ackerman SE, Chaudhary P, Keszenman DJ, Wilson PF. (2022). Dose-rate effects of protons and light ions for DNA damage induction, survival and transformation in apparently normal primary human fibroblasts. Radiat. Res. 197 (3): 298–313. doi: 10.1667/RADE-21-00138.1. PMID: 34910217.

Evans AC, Setzkorn T, Edmondson DA, Segelke H, Wilson PF, Matthay KK, Granger MM, Marachelian A, Haas-Kogan DA, DuBois, SG, Coleman MA. (2022). Peripheral blood transcript signatures after internal ¹³¹I-mIBG therapy in relapsed and refractory neuroblastoma patients identifies early and late biomarkers of internal ¹³¹I exposures. Radiat. Res. 197 (2): 101–112. doi: 10.1667/RADE-20-00173.1. PMID: 34673986.

2021

Johnson AM, Bennett PV, Sanidad KZ, Hoang A, Jardine JH, Keszenman DJ, Wilson PF. (2021). Evaluation of histone deacetylase inhibitors as radiosensitizers for proton and light ion radiotherapy. Front. Oncol. 11: 735940. doi: 10.3389/fonc.2021.735940. PMID: 34513712

2018

Low EK, Brudvik E, Kuhlman B, Wilson PF, Almeida-Porada G, Porada CD. (2018). Microgravity impairs DNA damage repair in human hematopoietic stem/progenitor cells and inhibits their differentiation into dendritic cells. Stem Cells Dev. 27 (18): 1257–1267. doi: 10.1089/scd.2018.0052. PMID: 29901426.

Almeida-Porada G, Rodman C, Kuhlman B, Brudvik E, Moon J, George S, Guida P, Sajuthi SP, Langefeld CD, Walker SJ, Wilson PF, Porada CD. (2018). Exposure of the bone marrow microenvironment to simulated solar and galactic cosmic radiation induces biological bystander effects on human hematopoiesis. Stem Cells Dev. 27 (18): 1237–1256. doi: 10.1089/scd.2018.0005. PMID: 29698131.

2017

Rodman C, Almeida-Porada G, George S, Moon J, Soker S, Pardee T, Beaty M, Guida P, Sajuthi SP, Langefeld CD, Walker SJ, Wilson PF, Porada CD. (2016). In vitro and in vivo assessment of direct effects of simulated solar and galactic cosmic radiation on human hematopoietic stem/progenitor cells. Leukemia 31 (6): 1398–1407. doi: 10.1038/leu.2016.344. PMID: 27881872.

2016

Wilson PF. (2016). Magnification of inter-individual variation in biological responses after low doses and dose-rates of ionizing radiation. Health Phys. 110 (3): 296–298. doi: 10.1097/HP.0000000000000453. PMID: 26808888.

2015

Yan X, Sasi SP, Gee H, Lee J, Yang Y, Mehrzad R, Onufrak J, Song J, Enderling H, Agarwal A, Rahimi L, Morgan J, Wilson PF, Carrozza J, Walsh K, Kishore R, Goukassian DA. (2015). Correction: Cardiovascular risks associated with low dose ionizing particle radiation.. PLoS One 10 (11). doi: 10.1371/journal.pone.0142764. PMID: 26544605.

2014

Yan X, Sasi SP, Gee H, Lee J, Yang Y, Mehrzad R, Onufrak J, Song J, Enderling H, Agarwal A, Rahimi L, Morgan J, Wilson PF, Carrozza J, Walsh K, Kishore R, Goukassian DA. (2015). Correction: Cardiovascular risks associated with low dose ionizing particle radiation.. PLoS One 9 (10). doi: 10.1371/journal.pone.0110269. PMID: 25337914.

Saha JP, Wilson PF, Thieberger P, Lowenstein D, Wang M, Cucinotta F. (2014). Biological characterization of low-energy ions with high-energy deposition on human cells. Radiat. Res. 182 (3): 282–291. 10.1667/RR13747.1.

Lin YF, Nagasawa H, Little JB, Kato TA, Shih HY, Xie XJ, Wilson PF, Brogan JR, Kurimasa A, Chen DJ, Bedford JS, Chen BP. (2014). Differential Radiosensitivity Phenotypes of DNA-PKcs Mutations Affecting NHEJ and HRR Systems following Irradiation with Gamma-Rays or Very Low Fluences of Alpha Particles. PloS One 9 (4): e93579. doi: 10.1371/journal.pone.0093579. PMID: 24714417.