The Thirty-Ninth Hanford Life Sciences Symposium "Cellular Communication-Information Processing at the Cell Surface" was held at the Pacific Northwest National Laboratory October 18-19, 2001. The symposium featured topics in the biological outcomes associated with cellular communication mediated at the cell surface, and distinguished scientists gathered to present their most recent work

Topics to be discussed included:

Session I. Passive Communication

1. Matrix
2. Cell-Cell Contact
3. Soluble Factors
4. Chemotaxis and Migration

Session II. Active Communication

1. Autocrine Signaling
2. Regulated Proteolysis
3. Growth Factors and Development

Pacific Northwest National Labs (PNNL) created new life science capabilities through its Laboratory-wide Biomolecular Networks Initiative (BNI) by exploiting the unique set of capabilities and innovative technologies housed in the Department of Energy's newest user facility, the William R. Wiley Environmental Molecular Sciences Laboratory (EMSL). The BNI is a multidisciplinary research program whose proteomics, cellular observatory, and virtual cell components deal with issues associated with integration of molecular biology biochemistry, physics, mathematics, and computer science to understand complex biological systems.

Genome sequences are providing the complete inventory of proteins that can potentially be expressed, and proteomics promises to provide the dynamic protein composition of cells changing in response to alterations in the cellular environment. However, knowing the parts is not sufficient for understanding how a biological system functions. The dynamic interactions of the parts in relation to both time and space must also be understood, and we must formulate theories of cell communication and test them experimentally. The symposium brings together scientists dedicated to understanding active and passive cellular communication at the cell surface.

Sponsors

Pacific Northwest National Laboratory

Symposium Co-Chairs:

Karin D. Rodland
Brian D. Thrall
Ronald A. Walters

Presenters

Dr. Anne G. Bang, Salk Institute
Dr. Roy Black, Immunex
Dr. Jan Christian, Oregon Health Sciences University
Dr. Peter Dempsey, Pacific Northwest Research Institute
Dr. Jason Haugh, North Carolina State University
Dr. Lynn Martisian, Vanderbilt University School of Medicine
Dr. Bruce Nicholson, SUNY Buffalo
Dr. Stanislav Shvartsman, Princeton, University
Dr. John Stanfield (Sandy) Parkinson, University of Utah
Dr. Alan H. Wells, University of Pittsburgh
Dr. Zena Werb (Parker Lecturer), U of California-San Francisco
Dr. Rabio Rossi, University of British Columbia

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