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Biological Sciences Staff information

Jennifer Kyle

IO Engagement & Performance
Scientist
Pacific Northwest National Laboratory
PO Box 999
MSIN: K8-98
Richland, WA 99352
509/375-3679

Research Interests

  • Lipidomics - in the environment and human systems
  • Mass Spectrometry

Education and Credentials

  • 2010 - 2012 NASA Postdoctoral Fellow, NASA Ames and Portland State University, USA
  • 2009 Ph.D. in Geology (specialized in geobiology), University of Toronto, Canada

Awards and Recognitions

  • 2015 PNNL Software Development Award
  • 2014 - 2015 Outstanding Performance Award, Pacific Northwest National Laboratory
  • 2010 - 2012 NASA Astrobiology Institute Postdoctoral Fellow

PNNL Publications

2017

  • Burnum-Johnson KE, JE Kyle, AJ Eisfeld, CP Casey, KG Stratton, JF Gonzalez, F Habyarimana, NM Negretti, AC Sims, S Chauhan, LB Thackray, P Halfmann, KB Walters, YM Kim, EM Zink, CD Nicora, KK Weitz, BJM Webb-Robertson, ES Nakayasu, B Ahmer, M Konkel, VL Motin, R Baric, MS Diamond, Y Kawaoka, KM Waters, RD Smith, and TO Metz. 2017. "MPLEx: A method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling." Analyst 142(3):442-448.  doi:10.1039/c6an02486f
  • Dautel SE, JE Kyle, GCD Clair, RL Sontag, KK Weitz, AK Shukla, SN Nguyen, YM Kim, EM Zink, T Luders, C Frevert, SA Gharib, J Laskin, JP Carson, TO Metz, RA Corley, and CK Ansong. 2017. "Lipidomics reveals dramatic lipid compositional changes in the maturing postnatal lung." Scientific Reports 7:Article No. 40555.  doi:10.1038/srep40555
  • Kyle JE, CP Casey, KG Stratton, EM Zink, YM Kim, X Zheng, ME Monroe, KK Weitz, KJ Bloodsworth, DJ Orton, YM Ibrahim, RJ Moore, C Lee, C Pedersen, ES Orwoll, RD Smith, KE Burnum-Johnson, and EM Baker. 2017. "Comparing Identified and Statistically Significant Lipids and Metabolites in 15-Year Old Serum and Dried Blood Spot Samples for Longitudinal Studies." Rapid Communications in Mass Spectrometry 31(5):447-456.  doi:10.1002/rcm.7808

2016

  • Kyle JE, X Zhang, KK Weitz, ME Monroe, YM Ibrahim, RJ Moore, J Cha, X Sun, ES Lovelace, J Wagoner, S Polyak, TO Metz, SK Dey, RD Smith, KE Burnum-Johnson, and ES Baker. 2016. "Uncovering Biologically Significant Lipid Isomers with Liquid Chromatography, Ion Mobility Spectrometry and Mass Spectrometry." Analyst 141(5):1649-1659.  doi:10.1039/C5AN02062J
  • Lanekoff I, J Cha, JE Kyle, SK Dey, J Laskin, and KE Burnum-Johnson. 2016. "Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site." Scientific Reports 6:Article No. 33023.  doi:10.1038/srep33023
  • Nakayasu ES, CD Nicora, AC Sims, KE Burnum-Johnson, YM Kim, JE Kyle, MM Matzke, AK Shukla, RK Chu, AA Schepmoes, JM Jacobs, R Baric, BJM Webb-Robertson, RD Smith, and TO Metz. 2016. "MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses." mSystems 1(3):e00043-16.  doi:10.1128/mSystems.00043-16
  • Rivas Ubach A, JA Hodar, J Sardans, JE Kyle, YM Kim, M Oravec, O Urban, AB Guenther, and J Penuelas. 2016. "Are the metabolomic responses to folivory of closely related plant species linked to macroevolutionary and plant-folivore coevolutionary processes?" Ecology and Evolution 6(13):4372-4386.  doi:10.1002/ece3.2206
  • Tisoncik-Go J, DJ Gasper, JE Kyle, AJ Eisfeld, C Selinger, M Hatta, J Morrison, MJ Korth, EM Zink, YM Kim, AA Schepmoes, CD Nicora, SO Purvine, KK Weitz, X Peng, R Green, SC Tilton, BJM Webb-Robertson, KM Waters, TO Metz, RD Smith, Y Kawaoka, M Suresh, L Josset, and MG Katze. 2016. "Integrated Omics Analysis of Pathogenic Host Responses during Pandemic H1N1 Influenza Virus Infection: The Crucial Role of Lipid Metabolism." Cell Host & Microbe 19(2):254-66.  doi:10.1016/j.chom.2016.01.002
  • Wang M, JJ Carver, VV Phelan, LM Sanchez, N Garg, Y Peng, DD Nguyen, JD Watrous, CA Kapono, T Luzzatto-Knaan, C Porto, A Bouslimani, AV Melnik, MJ Meehan, WT Liu, M Crusemann, PD Boudreau, E Esquenazi, M Sandoval-Calderon, R Kersten, LA Pace, RA Quinn, KR Duncan, CC Hsu, DJ Floros, RG Gavilan, K Kleigrewe, TR Northen, RJ Dutton, D Parrot, EE Carlson, B Aigle, CF Michelsen, L Jelsbak, C Sohlenkamp, PA Pevzner, A Edlund, JS Mclean, J Piel, BT Murphy, L Gerwick, CC Liaw, YL Yang, HU Humpf, M Maansson, RA Keyzers, AC Sims, A Johnson, AM Sidebottom, BE Sedio, A Klitgaard, CB Larson, CA Boya P, D Torres-Mendoza, D Gonzalez, JR, DB Silva, LM Marques, DP Demarque, E Pociute, EC O'Neill, E Briand, EJ Helfrich, EA Granatosky, E Glukhov, F Ryffel, H Houson, H Mohimani, JJ Kharbush, Y Zeng, JA Vorholt, KL Kurita, P Charusanti, KL McPhail, KF Nielsen, L Vuong, M Elfeki, MF Traxler, N Engene, N Koyama, OB Vining, R Baric, RR Silva, SJ Mascuch, S Tomasi, S Jenkins, V Macherla, T Hoffman, V Agarwal, PG Williams, J Dai, R Neupane, J Gurr, AM Rodriguez, A Lamsa, C Zhang, K Dorrestein, BM Duggan, J Almaliti, PM Allard, P Phapale, LF Nothias, T Alexandrov, M Litaudon, JL Wolfender, JE Kyle, TO Metz, T Peryea, DT Nguyen, D VanLeer, P Shinn, A Jadhav, R Muller, KM Waters, W Shi, X Liu, L Zhang, R Knight, PR Jensen, BO Palsson, K Pogliano, RG Linington, M Gutierrez, NP Lopes, WH Gerwick, BS Moore, PC Dorrestein, and N Bandeira. 2016. "Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking." Nature Biotechnology 34(8):828-837.  doi:10.1038/nbt.3597

2015

  • Lovelace ES, J Wagoner, J MacDonald, T Bammler, J Bruckner, J Brownell, R Beyer, EM Zink, YM Kim, JE Kyle, BJM Webb-Robertson, KM Waters, TO Metz, F Farin, NH Oberlies, and S Polyak. 2015. "Silymarin Suppresses Cellular Inflammation By Inducing Reparative Stress Signaling." Journal of Natural Products 78(8):1990-2000.  doi:10.1021/acs.jnatprod.5b00288
  • Touchette MH, GR Bommineni, RJ Delle Bovi, J Gadbery, CD Nicora, AK Shukla, JE Kyle, TO Metz, DW Martin, NS Sampson, WT Miller, PJ Tonge, and JC Seeliger. 2015. "Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl ß-Diol Lipids." Biochemistry 54(35):5457-5468.  doi:10.1021/acs.biochem.5b00455
  • Zhang X, YM Ibrahim, TC Chen, JE Kyle, RV Norheim, ME Monroe, RD Smith, and ES Baker. 2015. "Enhancing Biological Analyses with Three Dimensional Field Asymmetric Ion Mobility, Low Field Drift Time Ion Mobility and Mass Spectrometry (µFAIMS/IMS-MS) Separations." Analyst 140:6955-6963.  doi:10.1039/c5an00897b

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