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Biological Sciences Staff information

Jordan Smith

Systems Toxicology & Exposure Science
Scientist
Pacific Northwest National Laboratory
PO Box 999
MSIN: J4-02
Richland, WA 99352
509/371-6801

Awards and Recognitions

  • DOE Outstanding Mentor Award, 2010

PNNL Publications

2013

  • Teeguarden JG, C Housand, JN Smith, PM Hinderliter, R Gunawan, and C Timchalk. 2013. "A Multi-Route Model of Nicotine-Cotinine Pharmacokinetics, Pharmacodynamics and Brain Nicotinic Acetylcholine Receptor Binding in Humans." Regulatory Toxicology and Pharmacology 65(1):12-28.  doi:10.1016/J.YRTPH.2012.10.007
  • Lanekoff IT, M Thomas, JP Carson, JN Smith, C Timchalk, and J Laskin. 2013. "Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption Electrospray Ionization Mass Spectrometry." Analytical Chemistry 85(2):882-889.  doi:10.1021/ac302308p
  • Zhang W, Y Tang, D Du, JN Smith, C Timchalk, D Liu, and Y Lin. 2013. "Direct analysis of trichloropyridinol in human saliva using an Au nanoparticles-based immunochromatographic test strip for biomonitoring of exposure to chlorpyrifos." Talanta 114:261-267.  doi:10.1016/j.talanta.2013.06.012

2012

  • Smith JN, J Wang, Y Lin, EM Klohe, and C Timchalk. 2012. "Pharmacokinetics and Pharmacodynamics of Chlorpyrifos and 3,5,6-Trichloro-2-pyridinol in Rat Saliva After Chlorpyrifos Administration." Toxicological Sciences 130(2):245-256.  doi:10.1093/toxsci/kfs251
  • Timchalk C, JN Smith, AL Hjerpe, TS Poet, and SK Lee. 2012. "Regional Brain Dosimetry for the Organophosphorus Insecticide Chlorpyrifos in the Preweanling Rat." Chapter 13 in Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment. ACS Symposium Series, vol. 1099, ed. JB Knaak, C Timchalk and R Tornero-Velez, pp. 195-213.  American Chemical Society, Washington DC. 

2011

  • Smith JN, C Timchalk, MJ Bartels, and TS Poet. 2011. "In Vitro Age-Dependent Enzymatic Metabolism of Chlorpyrifos and Chlorpyrifos-Oxon in Human Hepatic Microsomes and Chlorpyrifos-Oxon in Plasma." Drug Metabolism and Disposition 39(8):1353-1362.  doi:10.1124/dmd.111.038745
  • Du D, J Wang, L Wang, D Lu, JN Smith, C Timchalk, and Y Lin. 2011. "Magnetic Electrochemical Sensing Platform for Biomonitoring of Exposure to Organophosphorus Pesticides and Nerve Agents Based on Simultaneous Measurement of Total Enzyme Amount and Enzyme Activity ." Analytical Chemistry 83(10):3770-3777.  doi:10.1021/ac200217d
  • Ellison CA, JN Smith, PJ Lein, and JR Olson. 2011. "Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos." Toxicology 287(1-3):137-144.  doi:10.1016/j.tox.2011.06.010
  • Lee SK, TS Poet, JN Smith, AL Hjerpe, R Gunawan, and C Timchalk. 2011. "IMPACT OF REPEATED NICOTINE AND ALCOHOL COEXPOSURE ON IN VITRO AND IN VIVO CHLORPYRIFOS DOSIMETRY AND CHOLINESTERASE INHIBITION." Journal of Toxicology and Environmental Health Part A 74(20):1334-50. 
  • Wang L, D Du, D Lu, CT Lin, JN Smith, C Timchalk, F Liu, J Wang, and Y Lin. 2011. "Enzyme-linked immunosorbent assay for detection of organophosphorylated butyrylcholinesterase: A biomarker of exposure to organophosphate agents." Analytica Chimica Acta 693(1-2):1-6. 
  • Wang L, D Lu, J Wang, D Du, Z Zou, H Wang, JN Smith, C Timchalk, F Liu, and Y Lin. 2011. "A Novel Immunochromatographic Electrochemical Biosensor for Highly Sensitive and Selective Detection of Trichloropyridinol, a Biomarker of Exposure to Chlorpyrifos." Biosensors and Bioelectronics 26(6):2835-2840 .  doi:10.1016/j.bios.2010.11.008

2010

  • Busby-Hjerpe AL, JA Campbell, JN Smith, S Lee, TS Poet, D Barr, and C Timchalk. 2010. "Comparative Pharmacokinetics of Chlorpyrifos versus its Major Metabolites Following Oral Administration in the Rat." Toxicology 268(1-2):55-63.  doi:10.1016/j.tox.2009.11.022
  • Lee S, TS Poet, JN Smith, AL Busby-Hjerpe, and C Timchalk. 2010. "Effect of In Vivo Nicotine Exposure on Chlorpyrifos Pharmacokinetics and Pharmacodynamics in Rats ." Chemico-Biological Interactions 184(3):449-457. 
  • Lee SK, TS Poet, JN Smith, AL Busby-Hjerpe, and C Timchalk. 2010. "Effect of in vivo nicotine exposure on chlorpyrifos pharmacokinetics and pharmacodynamics in rats." Chemico-Biological Interactions 184(3):449-457.  doi:10.1016/j.cbi.2010.01.024
  • Smith JN, J Wang, Y Lin, and C Timchalk. 2010. "Pharmacokinetics of the Chlorpyrifos Metabolite 3,5,6-Trichloro-2-Pyridinol (TCPy) in Rat Saliva." Toxicological Sciences 132(2):315-325. 
  • Zou Z, D Du, J Wang, JN Smith, C Timchalk, YQ Li, and Y Lin. 2010. "Quantum Dot-Based Immunochromatographic Fluorescent Biosensor for Biomonitoring Trichloropyridinol, a Biomarker of Exposure to Chlorpyrifos." Analytical Chemistry 82(12):5125-5133.  doi:10.1021/ac100260m

2009

  • Du D, J Wang, JN Smith, C Timchalk, and Y Lin. 2009. "Biomonitoring of Organophosphorus Agent Exposure by Reactivation of Cholinesterase Enzyme Based on Carbon Nanotube-Enhanced Flow-Injection Amperometric Detection ." Analytical Chemistry 81(22):9314-9320. 
  • Smith JN, JA Campbell, AL Busby-Hjerpe, S Lee, TS Poet, D Barr, and C Timchalk. 2009. "Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration in the adult rat." Toxicology 261(1-2):47-58.  doi:10.1016/j.tox.2009.04.041

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