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Biological Sciences Staff information

Karl Weitz

Omic, Inst, Infra & Inform
Scientist
Pacific Northwest National Laboratory
PO Box 999
MSIN: K8-98
Richland, WA 99352
509/371-6348

PNNL Publications

2013

  • Su D, AK Shukla, B Chen, JS Kim, ES Nakayasu, Y Qu, UK Aryal, KK Weitz, TRW Clauss, ME Monroe, DG Camp, II, DJ Bigelow, RD Smith, RN Kulkarni, and W Qian. 2013. "Quantitative Site-specific Reactivity Profiling of S-Nitrosylation in Mouse Skeletal Muscle Using Cysteinyl Peptide Enrichment Coupled with Mass Spectrometry." Free Radical Biology & Medicine 57:68-78.  doi:10.1016/j.freeradbiomed.2012.12.010

2012

  • Perera RM, C Riley, G Isaac, A Hopf- Jannasch, RJ Moore, KK Weitz, L Pasa-Tolic, TO Metz, J Adamec, and RJ Kuhn. 2012. "Dengue Virus Infection Perturbs Lipid Homeostasis in Infected Mosquito Cells." PLoS Pathogens 8(3):Article No. e1002584.  doi:10.1371/journal.ppat.1002584
  • Wang L, UK Aryal, Z Dai, AC Mason, ME Monroe, Z Tian, J Zhou, D Su, KK Weitz, T Liu, DG Camp, II, RD Smith, SE Baker, and W Qian. 2012. "Mapping N-linked Glycosylation Sites in the Secretome and Whole Cells of Aspergillus niger Using Hydrazide Chemistry and Mass Spectrometry." Journal of Proteome Research 11(1):143-56.  doi:10.1021/pr200916k

2011

  • Belov ME, S Prasad, DC Prior, WF Danielson, III, KK Weitz, YM Ibrahim, and RD Smith. 2011. "Pulsed Multiple Reaction Monitoring Approach to Enhancing Sensitivity of a Tandem Quadrupole Mass Spectrometer." Analytical Chemistry 83(6):2162-2171.  doi:10.1021/ac103006b
  • Carney EW, B Tornesi, AB Liberacki, DA Markham, KK Weitz, T Luders, KG Studniski, JC Blessing, Jr, RA Gies, and RA Corley. 2011. "The Impact of Dose Rate on Ethylene Glycol Developmental Toxicity and Pharmacokinetics in Pregnant CD Rats ." Toxicological Sciences 119(1):178-188.  doi:10.1093/toxsci/kfq310
  • Ghazalpour A, B Bennett, VA Petyuk, L Orazco, R Hagopian, I Mungrue, CR Farber, J Sinsheimer, HM Kang, N Furlotte, C Park, PZ Wen, HM Brewer, KK Weitz, DG Camp, II, C Pan, R Yordanova, I Neuhaus, C Tilford, N Siemers, P Gargalovic, E Eskin, T Kirchgessner, DJ Smith, RD Smith, and AJ Lusis. 2011. "Comparative Analysis of Proteome and Transcriptome Variation in Mouse." PLoS Genetics 7(6):Article No. e1001393.  doi:10.1371/journal.pgen.1001393
  • Lee B, D Lopez-Ferrer, BC Kim, HB Na, YI Park, KK Weitz, MG Warner, T Hyeon, SW Lee, RD Smith, and J Kim. 2011. "Rapid and Efficient Protein Digestion using Trypsin Coated Magnetic Nanoparticles under Pressure Cycles." Proteomics 11(2):309-318.  doi:10.1002/pmic.201000378
  • Lopez-Ferrer D, K Petritis, EW Robinson, KK Hixson, Z Tian, JH Lee, SW Lee, N Tolic, KK Weitz, ME Belov, RD Smith, and L Pasa-Tolic. 2011. "Pressurized Pepsin Digestion in Proteomics: An Automatable Alternative to Trypsin for Integrated Top-down Bottom-up Proteomics." Molecular & Cellular Proteomics. MCP 10(2):, doi:10.1074/mcp.M110.001479

2010

  • Bagwell CE, KK Hixson, CE Milliken, D Lopez-Ferrer, and KK Weitz. 2010. "Proteomic and Physiological Responses of Kineococcus radiotolerans to Copper." PLoS One 5(8):Article No. e12427.  doi:10.1371/journal.pone.0012427
  • Lewis NE, KK Hixson, TM Conrad, JA Lerman, P Charusanti, AD Polpitiya, JN Adkins, G Schramm, SO Purvine, D Lopez-Ferrer, KK Weitz, R Eils, R Konig, RD Smith, and BO Palsson. 2010. "Omic data from evolved E. coli are consistent with computed optimal growth from genome-scale models." Molecular Systems Biology 6:Article No. 390.  doi:10.1038/msb.2010.47
  • Zhang X, J Zhou, MH Chin, AA Schepmoes, VA Petyuk, KK Weitz, BO Petritis, ME Monroe, DG Camp, II, SA Wood, WP Melega, DJ Bigelow, DJ Smith, W Qian, and RD Smith. 2010. " Region-Specific Protein Abundance Changes in the Brain of MPTP-induced Parkinson's Disease Mouse Model ." Journal of Proteome Research 9(3):1496-1509.  doi:10.1021/pr901024z

2009

  • Zhou J, BO Petritis, K Petritis, AD Norbeck, KK Weitz, RJ Moore, DG Camp, II, RN Kulkarni, RD Smith, and W Qian. 2009. "Mouse-Specific Tandem IgY7-SuperMix Immunoaffinity Separations for Improved LC-MS/MS Coverage of the Plasma Proteome ." Journal of Proteome Research 8(11):5387-5395. 

2006

  • Timchalk C, Y Lin, KK Weitz, H Wu, RA Gies, DA Moore, and W Yantasee. 2006. "Disposition of Lead (Pb) in Saliva and Blood of Sprague-Dawley Rats Following a Single or Repeated Oral Exposure to Pb-Acetate." Toxicology 222(1-2):86-94.  doi:10.1016/j.tox.2006.01.030

2005

  • Corley RA, RA Gies, H Wu, and KK Weitz. 2005. "DEVELOPMENT OF A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR PROPYLENE GLYCOL MONOMETHYL ETHER AND ITS ACETATE IN RATS AND HUMANS." Toxicology Letters 156(1):193-213. 
  • Corley RA, DM Grant, E Farris, KK Weitz, JJ Soelberg, KD Thrall, and TS Poet. 2005. "DETERMINATION OF AGE AND GENDER DIFFERENCES IN BIOCHEMICAL PROCESSES AFFECTING THE DISPOSITION OF 2-BUTOXYETHANOL AND ITS METABOLITES IN MICE AND RATS TO IMPROVE PBPK MODELING." Toxicology Letters 156(1):127-161. 
  • Corley RA, MJ Bartels, EW Carney, KK Weitz, JJ Soelberg, RA Gies, and KD Thrall. 2005. "DEVELOPMENT OF A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR ETHYLENE GLYCOL AND ITS MAJOR METABOLITE, GLYCOLIC ACID, IN RATS AND HUMANS." Toxicological Sciences 85(1):476-490. 
  • Yantasee W, C Timchalk, KK Weitz, DA Moore, and Y Lin. 2005. "Optimization of A Portable Microanalytical System to Reduce Electrode Fouling from Proteins Associated with Biomonitoring of Lead (Pb) in Saliva." Talanta 67(3):617-624. 

2003

  • Kimzey AL, KK Weitz, FP Guengerich, and RC Zangar. 2003. "Hydroperoxy-10,12-octadecadienoic acid stimulates cytochrome P450 3A protein aggregation by a mechanism that is inhibited by substrate." Biochemistry 42(43):12691-12699. 
  • Poet TS, JJ Soelberg, KK Weitz, TJ Mast, RA Miller, BD Thrall, and RA Corley. 2003. "Mode of Action and Pharmacokinetic Studies of 2-Butoxyethanol in the Mouse with an Emphasis on Forestomach Dosimetry." Toxicological Sciences 71(2):176-189. 
  • Thrall KD, RE Schwartz, KK Weitz, JJ Soelberg, GL Foureman, JD Prah, and C Timchalk. 2003. "A Real-time Method to Evaluate the Nasal Deposition and Clearance of Acetone in the Human Volunteer." Inhalation Toxicology 15(6):523-538. 

2001

  • Thrall KD, PJ Callahan, KK Weitz, JA Edwards, MC Brinkman, and DV Kenny. 2001. "Design and evaluation of a breath-analysis system for biological monitoring of volatile compounds." American Industrial Hygiene Association Journal 62(1):28-35. 
  • Timchalk C, TS Poet, Y Lin, KK Weitz, R Zhao, and KD Thrall. 2001. "Development of an Integrated Micro-Analytical System for Lead in Saliva and Linkage to a Physiologically Based Pharmacokinetic Model Describing Lead Saliva Secretion ." American Industrial Hygiene Association Journal 62(3):295-302. 

2000

  • Poet TS, KD Thrall, RA Corley, XY Hui, JA Edwards, KK Weitz, HI Maibach, and RC Wester. 2000. "Utility of real time breath analysis and physiologically based pharmacokinetic modeling to determine the percutaneous absorption of methyl chloroform in rats and humans ." Toxicological Sciences 54(1):42-51. 
  • Poet TS, RA Corley, KD Thrall, JA Edwards, H Tanojo, KK Weitz, X Hui, HI Maibach, and RC Wester. 2000. "Assessment of the Percutaneous Absorption of Trichloroethylene in Rats and Humans Using MS/MS Real Time Breath Analysis and Physiologically Based Pharmacokinetic Modeling." Toxicological Sciences 56(1):61-72. 
  • Thrall KD, TS Poet, RA Corley, H Tanojo, JA Edwards, KK Weitz, X Hui, HI Maibach, and RC Wester. 2000. "A Real-Time In-vivo Method for Studying the Percutaneous Absorption of Volatile Chemicals." International Journal of Occupational Environmental Health 6(2):96-103. 
  • Thrall KD, ME Vucelick, RA Gies, RC Zangar, KK Weitz, TS Poet, DL Springer, DM Grant, and JM Benson. 2000. "Comparative Metabolism of Carbon Tetrachloride in Rats, Mice and Hamsters Using Gas Uptake and PBPK Modeling." Journal of Toxicology and Environmental Health 60(8):531-548. 

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