Contact: Dr. Thomas Metz
We are establishing a leading metabolomics capability at PNNL by leveraging existing proteomics capabilities and developing new capabilities to provide metabolomics support to the BS&MS Group and EMSL users.
These capabilities include global measurements performed using ultra-performance liquid chromatography (UPLC) coupled with mass spectrometry, as well as targeted measurements performed using high-performance liquid chromatography (HPLC) or gas chromatography (GC) coupled with triple quadrupole mass spectrometry.
Current focus areas of our Metabolomics Section include the application of global metabolomics and lipidomics, as well as targeted metabolite analyses, to biological systems to better understand both disease pathogenesis and fundamental biology.
Lipidomics is a rapidly expanding area of metabolomics research in which multiple techniques are used to quantify the hundreds of chemically distinct lipids in cells and to determine the molecular mechanism(s) through which they facilitate cellular function. Lipidomics is also important to the understanding of functional implications via profiling of lipid abnormalities in biofluids, which could be used as potential biomarkers for disease.