Design (3): Interim analysis at n=17, possible total is 44

Interim

analysis

after 17,

continue

to 44 if

not 0-4

or 13-17;

P value

= 0.085

Both shaded regions = 0.049

Prob. both = 0.013;

net is 2(0.049) – 0.013

= 0.085

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