Frequentist hypothesis testing
P value = Probability of observing data as or more extreme than results, assuming H0: P = P(tail of dist. | H0)
Four designs:
(1) Observe 17 pairs
(2) Stop trial once both 4 A's and 4 B's
(3) Interim analysis at 17, stop if 0 - 4 or
13 - 17 A's, else continue to n = 44
(4) Stop when "enough information"